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The book begins with a general overview of Warburg Hypothesis, mitochondrial structure and function, and then outline more specifically the metabolic and molecular alterations in mitochondria that are associated with human cancer and their clinical implications. An emphasis is also placed on mtDNA mutations and their potential role in carcinogenesis. The potential use of mitochondria as biomarkers for early detection of cancer, or as unique cellular targets for novel and selective anti-cancer agents will also be discussed.

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COUNSELING ABOUT CANCER
Strategies for Genetic Counseling
Second Edition
Katherine Schneider

Counseling About Cancer is the comprehensive resource to help genetic counselors and other health care providers effectively assist patients and families through the emotional difficulties of managing hereditary cancer. Now, in its Second Edition, extensive revisions have been made to include up-to-date coverage of the medical and psychological issues surrounding cancer risk counseling, including the major hereditary cancer syndromes, components of cancer risk counseling sessions, and predisposition testing sessions.

In providing single-source coverage of this emerging field, this easy-to-use reference presents:

• Clinical features of 30 cancer syndromes
• Tables listing major cancer syndromes by cancer type
• Pedigrees illustrating the features of cancer syndromes as well as other family issues
• Practical advice on a range of responsibilities from collecting and interpreting histories to judging potential ethical dilemmas
• An ample number of detailed case studies

Counseling About Cancer is an essential reference for genetic counselors, physicians, and nurses working in clinical cancer services or oncology departments, genetic counseling students, and other health care professionals who need current, inclusive facts on genetic counseling at their fingertips. ... Read more

Customer Reviews (4)

Thorough resource
This book was required reading for my training program, but I have used it numerous times since graduation.This is a good resource for any genetic counselor or other medical professional who works with cancer patients.

Satisfied
Book was exactly what I expected. Shipping was prompt and the condition of the book was great.

Recommended Book
"...I would definitely recommend this book to other genetic counsellors and health-care professionals working directly with hereditary cancer syndromes." (Health Expectations)

"A Landmark Book"
"If you are counseling patients about cancer, this book belongs on your bookshelf.From student to healthcare professional, novice to expert, Katherine Schneider's book offers essential information about the clinical and genetic aspects of cancer, valuable guidance in risk assessment and helpful strategies for counseling patients. Katherine Schneider's succinct summaries of hereditary cancer syndromes and tables will be of great benefit in generating differential diagnoses, determining genetic testing options and what cancer screening is indicated. The case examples nicely tie together key concepts, address ethical dilemmas, illustrate the nuances of counseling and the psychological impact information has on patients and their families."Counseling About Cancer: Strategies for Genetic Counseling" is truly a landmark book in this rapidly evolving field." -- Wendy Uhlmann, M.S., University of Michigan ... Read more

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This volume addresses the question of how knowledge of epigenetic phenomena like DNA methylation and acetylation can be applied to early cancer detection and risk assessment. The objectives of the papers include defining the terminology used in epigenetics. ... Read more

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Schering-Plough Research Institute, Lafayette, NJ. Reviews various roles of genetic toxicology in human cancer risk assessment conducted by the U.S. and worldwide regulatory agencies. Discusses hazard identification, dose-response relationship, exposure assessment, and current practices of risk characterization. ... Read more

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Since the first volume was published, there has been significant success in isolating genes responsible for particular cancers as well as a major improvement in our understanding of the molecular events leading to tumors. This book explores possible genetic treatments that can suppress cancer cells that have formed tumors and it presents the details of the isolation and characterization of new human cancer genes that have recently been identified. Molecular Genetics of Cancer, 2E is an essential book for anyone involved in cancer research and the search for a cure. ... Read more

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Intensive research over the last fifteen years has yielded a vast expansion in our understanding of the role of inheritance and genetics in a variety of cancers. Several inherited conditions have been identified which result in a high risk of various cancers; some of these were previously recognised, but the genetic basis underlying them has now been elucidated. This knowledge is now entering the sphere of routine clinical care. Once the preserve of researchers and highly specialised units, genetic testing for cancer predisposition is now accessible to most clinicians via regional genetics units; in the USA patients can access commercial genetic testing facilities. There is a growing evidence base to guide family screening and clinical management of affected individuals.Surgeons, gastroenterologists, gynaecologists, oncologists, endocrinologists and many others need an awareness of these disorders, an understanding of genetic testing and when it is indicated, and how to manage patients with inherited cancer predisposition and their families.Testing for these conditions has potential legal, ethical and financial implications different from those which most clinicians regularly encounter, and continuing scientific and clinical advance means that patients and their doctors will face regular changes in management. This book covers the basic concepts of cancer genetics. The common inherited cancer syndromes are each dealt with in greater depth, with the current management outlined.This book is aimed at all clinicians who may encounter these conditions in their practice. It aims to facilitate identification of high-risk individuals and families, to inform interaction with geneticists and other sub-specialists, to provide a basis for patient management and to stimulate interest in these fascinating conditions. ... Read more

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Progress in sequencing and characterizing the human genome has transformed cancer genetics both conceptually and methodologically. In Prostate Cancer: Biology, Genetic, and the New Therapeutics, Second Edition, leading cancer biologists and clinical researchers comprehensively review the latest basic research and its translational significance for the molecular biology and genetics of prostate cancer, as well as its application in developing novel therapeutics. Highlights of recent molecular genetics research include new light on inactivated tumor suppressor genes, HPC families, the role of the androgen receptor, the progression of prostate cancer and promising results from transcriptome profiling and proteomics. Research into the basic biology and regulatory mechanisms controlling prostate cancer growth, progression and stromal-epithelial interaction has revealed many possibilities for therapeutic intervention, including cell adhesion molecules, the androgen receptor, use of the nuclear matrix, Caveolin-1, and the prostate-specific membrane antigen. Among the cancer therapeutic modalities discussed are chemoprevention, radiotherapy, radical retropubic prostatectomy, the development of dendritic-cell based vaccines, differntiation therapies, and gene therapy. ... Read more

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Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. In, “Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies”, the authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer research, such as laparoscopic radical prostatectomy, and offers a critical evaluation and discussion of opportunities for development of novel therapies for prostate cancer. Clinical trials that have not been covered or evaluated in any other books currently available are also discussed. Invaluable to physicians and researchers, “Prostate Cancer: Signaling Networks, Genetics, and New Treatment Strategies” provides a comprehensive translational resource as well as an important source of information for prostate cancer patients.

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Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk.

The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.

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The need to expand expertise in cancer genetics beyond highly specialized genetics clinics is increasingly being recognized.In response, this practical book provides oncologists, specialist nurses, genetic counsellors, family doctors, and geneticists with comprehensive and easy-to-use guidelines on risk assessment and appropriate management. The book focuses on common familial cancers such as breast, colorectal, ovary, prostate and melanoma, and separate chapters cover cancer predisposing syndromes such as neurofibromatosis, familial adenomatous polyposis and their management. ... Read more

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Knowledge about cancer genetics is rapidly expanding, and has implications for all aspects of cancer research and treatment, including molecular causation, diagnosis, prevention, screening, and treatment.

Additionally, while cancer genetics has traditionally focused on mutational events that have their primary effect within the cancer cell, recently the focus has widened, with evidence of the importance of epigenetic events and of cellular interactions in cancer development. The role of common genetic variation in determining the range of individual susceptibility within the population is increasingly recognized, and is now being widely addressed using information from the Human Genome Project. These new research directions will highlight determinants of cancer that lie outside the cancer cell, suggest new targets for intervention, and inform the design of strategies for prevention in groups at increased risk.

Today, the NCI is putting more and more money into research into the genetics of cancer. The very first of the NCI’s stated research priorities is a project called The Cancer Genome Atlas. The Cancer Genome Atlas (TCGA) is a comprehensive and coordinated effort to accelerate the understanding of the molecular basis of cancer through the application of genome analysis technologies, including large-scale genome sequencing. The NCI and the NHGRI (National Human Genome Research Institute, where the series editor is employed) have each committed $50 million over three years to the TCGA Pilot Project.

This book proposes cover the latest findings in the genetics of male reproductive cancers; specifically cancers of the prostate and testes. The volume will cover the epidemiology of these cancers; model systems, pathology, molecular genetics, and inherited susceptibility.

Product Description

• Offers a broad audience a concise presentation of the most up-to-date knowledge about the biology and treatment of cancer
• Full coverage of cancer prevention and control
• Clear, thorough discussion of current and possible future therapies
• Edited by two of the most eminent and widely recognized scholars of cancer research and therapeutics in the world, with contributions from top researchers and clinicians from across North America

Customer Reviews (1)

Understanding Cancer 301 - for advanced students
Great book - buy a new one (when the new editions come out) and read every 2-3 years so you are up to date on the latest in cancer treatment, diagnosis, and causation. ... Read more

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A comprehensive state-of-the-art summary of breast cancer research and treatment by leading authorities. The book's many distinguished contributors illuminate the biology and genetics of breast cancer, including what is known about the hereditary breast cancer genes, BRCA1 and 2, the cutting-edge cytogenic approaches, and the biology of breast cancer metastasis. In addition, the authors describe current and future methods of breast cancer treatment in depth, and discuss environment and diet as risk factors for the disease.Breast Cancer: Molecular Genetics, Pathogenesis, and Therapeutics constitutes an excellentreference and resource for all those clinical and experimental oncologists, as well as genetic counselors nurses, who need to understand the latest developments in breast cancer biology, risk, and treatment.



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This volume covers tumors of the pituary, the thyroid and parathyroid, the adrenal gland, the endocrine pancreas, and inherited tumor syndromes. Each entity is extensively discussed with information on clinicopathological, epidemiological, immunophenotypic and genetic aspects of these diseases. The book is an authoritative, concise reference, prepared by 150 authors from 20 countries. It contains more than 500 color photographs, numerous, MRIs, ultrasound images, CT scans, charts and more than 2900 references.

This book is in the series commonly referred to as the "Blue Book" series.
Pathology and Genetics of Tumors of Endocrine Organs

Contributors::Dr. Susan L. Abbondanzo, Dr. GoranAkerstrom, Dr. Lars Andreas Akslen, Dr. Jorgo Albores-Saavedra, Dr. Micheala A. Aldred, Dr. Katsuyki Aozasa, Dr. Andrew Arnold, Dr. Sylvia L. Asa, Dr. Zubair W. Baloch, Dr. Ariel L. Barkan, Dr. Bora E. Baysal, Dr. Gazanfer Belge, Dr. Xavier Bertagna, Dr. Wojciech Biernat, Dr. John P. Bilezikian, Dr. Scott Boerner, Dr. Tom Bohling, Dr. Lennart Bondeson, Dr. Ceasare Bordi, Dr. Gianni Bussolati, Dr. Blake Cady, Dr. Alain Calender, Dr. Jose Cameselle-Teijeiro, Dr. Carlo Capella, Dr. Maria Luise Carcanciu, Dr. J. Aiden Carney, Dr. Paul Caruso, Dr. Barbara Centeno, Dr. John K. C. Chan, Dr. Liang Cheng, Dr. Runjan Chetty, Dr. Wah Cheuk, Dr. George P. Chrousos, Dr. Orlo H. Clark, Dr. Randall D. Craver, Dr. Yogeshwar Dayal, Dr. Ronald R. De Krijger, Dr. Ronald A. Delellis, Dr. Kari-Michael Derwahl, Dr. David M. Dorfman, Carrlo Melvin Drovdlic, Dr. Damian E. Dupuy, Dr. Charles Eng, Dr. Vincenzo Eusebi, Dr. Harry L. Evans, Dr. D. Gareth Evans, Dr. Sheroon Ezzat, Dr. James A. Fagin, Dr. William Clay Faquin, Dr. Nadir R. Farid, Dr. P. Farid, Dr. William E. Farrell, Dr. William Foulkes, Dr. Kaarle O. Franssila, Dr. Robert F. Gagel, Dr. Kim R. Geisinger, Dr. Ronald A. Ghossein, Dr. Oliver Gimm, Dr. Thomas J. Giordano, Dr. Dario Guiffrida, Dr. Lara Grimelius, Dr. Gerardo Esteban Guiter, Dr. Philip I. Haigh, Dr. Hector Ruben Harach, Dr. Ian D. Hay, Dr. Philipp U. Heitz, Dr. Geoffrey N. Hendy, Dr. Mitsauyoshi Hirokawa, Dr. Eva Horvath, Dr. Leonard B. Kahn, Dr. Klaus Kaserer, Dr. Akiro Kawashima, Dr. Noriko Kimura, Dr. Yutaka Kitamura, Dr. Paul Kleihues, Dr. David S. Klimstra,Dr. Richard T. Kloos, Dr. Gunter Kloppel, Dr. Christian A. Koch, Dr. Paul Komminoth, Dr. George Kontogeorgos, Dr. Kalman Kovacs, Dr. Todd Gerard Kroll, Dr. Alfred King Yin Lam, Dr. Catherine Larsson, Dr. Juen Lechago, Dr. E. Paul Lindell, Dr. Virginia Livolsi, Dr. Ricardo V. Lloyd, Dr. M. Beatriz S. Lopes, Dr. Eamonn R. Maher, Dr. Xavier Matias-Guiu, Dr. Ernest L. Mazzaferri, Dr. Anne Marie McNicol, Dr. L. Jeffrey Medeiros, Dr. Maria J. Merino, Dr. Jeffrey F. Moley, Dr. Carl D. Morrison, Dr. Lois Mulligan, Dr. Katherine L. Nathanson, Dr. Hartmut P. Neumann, Dr. Yuri E. Nikiforov, Dr. Shiro Noguchi, Dr. Vania Nose, Professor Kjell Oberg, Dr. Nelson G. Ordonez, Dr. Josep Oriola, Dr. Robert Yoshiyuki Osamura, Dr. Mauro Papotti, Dr. Ralf Paschke, Dr. Juha Peltonen, Dr. Aurel Perren, Dr. Silvana Pilotti, Dr. Karl H. Plate, Dr. Hartmut M. Rabes, Dr. Guido Rindi, Dr. Fedorico Roncaroli, Dr. Sergio Vidal Ruibal, Dr. Wolfgang Saeger, Dr. Atsuhiko Sakamoto, Dr. Toshiaki Sano, Dr. Massimo Santoro, Dr. Hironobu Sasano, Dr. Bernd W. Scheithauer, Dr. Katherine A. Schneider, Dr. Arthur B. Schneider, Dr. Jean Yves Scoazec, Dr. Elizabeth Shane, Dr. Leslie H. Sobin, Dr. Manual Sobrinho-Simoes, Dr. Ernst J. M. Speel, Dr. Constantine A. Stratakis, Dr. Hugo Studer, Dr. Iwao Sugitani, Dr. Saul Suster, Mr. Kevin M. Sweet, Dr. Giovanni Tallini, Dr. Bin Tean The, Dr. Lester D.R. Thompson, Dr. Arthur S. Tischler, Dr. Jacqueline Trouillas, Dr. Thomas M. Ulbright, Dr. M. Volante, Dr. Petri.E. Voutilainen, Dr. Robert Watson, Dr. A. L. Weber, Dr. Loe S. Weinstein, Dr. Lawrence M. Weiss, Dr. Bruce M. Wenig, Dr. E. Dilwyn Williams, Dr. Shozo Yamada, Dr. William F. Young JR, Dr. Mauren Zakowski
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The availability of new molecular approaches to the selection of drug therapy is an emerging need, as the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many, and in most cases the majority of treated patients do not have significant benefits from the treatment while they often experience moderate to severe toxicities. In “Pharmacogenomics, Anticancer Drug Discovery, and Response”, edited by Federico Innocenti, readers will find a series of chapters addressing the role of genomic information in cancer therapy and in drug development representing a unique source, as it describes experimental approaches, statistical strategies, and clinical examples of the application of genomic medicine in oncology. This book provides the most comprehensive body of knowledge on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients.

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Addenbrooke's Hospital, Cambridge, U.K. Current clinical research on the genetic basis of cancer, for clinicians and researchers. 42 contributors, 28 U.S. ... Read more

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Tulane Medical School, New Orleans, LA. Provides a comprehensive review of recent developments in cancer genetics and biology. For researchers, clinicians, and students. Five sections discuss the genetic basis of cancer, while one section deals with the role of methylation and imprinting in cancer. DNLM: Neoplasms--genetics. ... Read more

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The goal of this work is summarize the contribution that insertional mutagenesis has made to our understanding of cancer. A variety of insertional mutagens are presented that have been used to study a variety of tumor types in several model organisms. In addition, the impact of insertional mutagenesis in several gene therapy trials is discussed along with strategies to avoid such complications in future clinical trials. ... Read more

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Series Editors Keith James, University of Edinburgh Medical School, UK. Alan Morris, University of Warwick, UK This series is designed to bridge the gap between pure research in the biomedical sciences and its practical application in clinical medicine. The objective is to promote the understanding of the molecular basis of human physiology and disease, and new techniques for diagnosis and treatment. Primarily intended for graduate students of medicine, the books will also be of use to molecular biologists, biochemists, physiologists, pharmacologists and biotechnologists, as well as medical practitioners and technicians who seek to update their knowledge. Introduction to the Molecular Genetics of Cancer Edited by Richard G. Vile Imperial Cancer Research Fund, London, UK There are increasingly hopeful indications that definition of the molecular defects within cancer cells may soon lead to improved therapeutic regimens for the patient. This book discusses the roles both of the dominantly acting cellular oncogenes and of the ‘recessive’ tumour suppressor genes as well as the importance of viral oncogenes in the genesis of human cancers. In addition, it highlights the potential to exploit the fine detail differences between the aberrant growth characteristics of the cancer cell and its normal counterpart which may lead to therapeutic advances in the treatment of cancer. It also aims to generate a more general perspective on the genetic contributions to carcinogenesis as an integrated disease process. Thus, it will be of value to researchers, clinicians, and students of cell and molecular biology, genetics and biochemistry who want a portal to the vast literature on the molecular mechanisms of cancer. ... Read more