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This digital document is an article from Skin & Allergy News, published by International Medical News Group on June 1, 2003. The length of the article is 638 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Patients fear discrimination based on genetic tests. (Breast Cancer History).
Author: Mitchel L. Zoler
Publication: Skin & Allergy News (Magazine/Journal)
Date: June 1, 2003
Publisher: International Medical News Group
Volume: 34Issue: 6Page: 38(1)

Distributed by Thomson Gale ... Read more

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Mutagenesis Laboratory, Herts, U.K. Survey of the current research on genetics and mutations in cancer, for investigators. ... Read more

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This book presents a systematic treatment of Markov chains, diffusion processes and state space models, as well as alternative approaches to Markov chains through stochastic difference equations and stochastic differential equations. It illustrates how these processes and approaches are applied to many problems in genetics, carcinogenesis, AIDS epidemiology and other biomedical systems.

One feature of the book is that it describes the basic MCMC (Markov chain and Monte Carlo) procedures and illustrates how to use the Gibbs sampling method and the multilevel Gibbs sampling method to solve many problems in genetics, carcinogenesis, AIDS and other biomedical systems.

As another feature, the book develops many state space models for many genetic problems, carcinogenesis, AIDS epidemiology and HIV pathogenesis. It shows in detail how to use the multilevel Gibbs sampling method to estimate (or predict) simultaneously the state variables and the unknown parameters in cancer chemotherapy, carcinogenesis, AIDS epidemiology and HIV pathogenesis. As a matter of fact, this book is the first to develop many state space models for many genetic problems, carcinogenesis and other biomedical problems. ... Read more

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This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. ... Read more

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This publication is a testament to how far the field of genetic counseling for breast cancer susceptibility has advanced since the mid-1990s, following the cloning of two major breast (and ovarian) cancer susceptibility genes, BRCA1 and BRCA2. For women who test positive, several recent studies confirm what we suspected early on namely that prophylactic mastectomy and oophorectomy confer significant protection against the development of breast and ovarian cancer. Ongoing research to develop better screening measures for ovarian cancer is especially critical now given the substantial number of women who are identified by BRCA1/2 positive status as being at high risk for this disease. In addition, we are learning more about other genetic contributions to familial breast cancer risk including low penetrance gene mutations, SNPs (single nucleotide polymorphisms) and mutations in modifier genes. In this continuum of learning and awareness, it is the shared efforts of policy-makers, researchers, healthcare providers, theologians, ethicists, consumers, and others who will navigate us through and beyond the genetics nexus. As a community, we have a window of opportunity to embrace lessons learned from cancer genetic counseling and extrapolate them to other pursuits of genetic knowledge.

IOS Press is an international science, technical and medical publisher of high-quality books for academics, scientists, and professionals in all fields.

Some of the areas we publish in:

-Biomedicine
-Oncology
-Artificial intelligence
-Databases and information systems
-Maritime engineering
-Nanotechnology
-Geoengineering
-All aspects of physics
-E-governance
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-The knowledge economy
-Urban studies
-Arms control
-Understanding and responding to terrorism
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Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information.

* Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells
* Examines the role of genetic recombination in cancer including cancer invasion and metastasis
* Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers ... Read more

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This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers. This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators. ... Read more

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The theory of natural systems is unique in that:¿ It is the only theory that unifies all physical reality postulating that elemental reality and natural systems have the essential capability to decide and to make meaning out of information. Artificial systems do not have such faculties.¿ It encompasses physical and biological energies into control-energies based in the quantitative and qualitative content of information.¿ It sees universal evolution -from elemental matter to systems- due to a spontaneous drive to associate essential to all physical reality.¿ It ends the obsolete notions of body-soul duality, chance as cause of action, laws of nature, etc. , unchallenged since the beginning of the 20th century.¿ It is the theoretical foundation of Clinical Biofeedback widely practiced today. Voluntary control of one brain cell out of the 10 billion cells in the brain has been successfully achieved by Clinical Biofeedback. ¿ Clinical Genetic Biofeedback, the voluntary control of the genetic machinery, is the next medical step that this theory proposes and the only possible cure of cancer and AIDS. ¿ By Clinical Genetic Biofeedback erroneous DNA can be corrected or re-programmed to stimulate immune reactions. Drugs and present medical therapies have no other theoretical capabilities than to cripple or amputate the DNAs of the cancer and AIDS patient rather than to cure them. ... Read more

Customer Reviews (10)

A Substantial Work and Solid Presentation
Over the past few years, I've read several books that discuss quantum mechanics and related physics. As I read The Theory of Natural Systems, it became obvious to me that the author, Dr. Gaydos, has read more extensively on those subjects than I have. Plus, she has a doctorate in chemistry and significant experience in that field.

The goal of her book, The Theory of Natural Systems, is to prod the medical research community to explore an alternative to the standard protocol of "burn you, poison you, cut you" that conventional medicine follows in response to cancer and AIDS (and most other ailments). About half the book lays the foundation for getting to the logic from which springs the conclusion.

Dr. Gaydos covers some heavy material without making the reader's eyes glaze over. Maybe her explanations seem straightforward to me because I have a quantitative background and am used to seeing concepts expressed via the methods she uses. If you don't have a quantitative background and you don't have an interest in science, then you may find this book a bit daunting. If so, then you will also find the effort to read it does not go unrewarded.

Dr. Gaydos followed the traditional thesis format of presenting facts, then arguments, then conclusions, then recommendations.

This is in stark contrast to the increasingly common practice of peddling fiction as nonfiction (e.g., An Inconvenient Truth, which was inconveniently untrue) to push a personal agenda. Too many authors (and speakers and screen-writers) cherry-pick facts and/or present false assertions as fact to support a presumptive conclusion, regardless of overwhelming evidence refuting that conclusion.

In addition to playing fair in the intellectual realm, good science books educate the reader. This one is no exception. By reading The Theory of Natural Systems, I received a several well-presented lessons in the fascinating fields of quantum physics, astrophysics, chemistry, and biology. Any one of these, by itself, is worth the "price of admission."

The concept of evolution is a cornerstone of science, and most disciplines of science are impenetrable unless you grasp this concept. Reading The Theory of Natural Systems helped deepen my understanding of the evolutionary process, and it helped me see how it applies to systems of all types--even star systems. Consequently, reading this book has improved my ability to understand and enjoy other scientific texts I will read in the future.

Side note: I was distraught when the Kansas legislature caved in to people who are highly vocal about their sixth century beliefs. Kansas undermined education in science by making it public policy to deny the Theory of Evolution. In scientific parlance, the word "theory" does not mean "maybe." Fortunately, the damage of this bad policy soon became clear and the legislature promptly repealed it. Unfortunately, some of that damage was permanent. For example, prominent researchers in Life Science relocated to Europe out of concern for their school-age children.

Providing a summary of this book is challenging, to say the least. That's not because of some deficiency in the text, but because the text is so rich. So, I will make do with comments on selected chapters (there are sixteen of them).

After discussing the concept of identity and its relation to reality in Chapter One, Dr. Gaydos postulates in Chapter Two that the universe itself has identity and can make decisions. Chapter Two builds to its conclusion that elemental particles have free will.

Chapter Six explores general and universal laws. Here, Dr. Gaydos lays the groundwork upon which she later mathematically shows the absurdity of the idea that our orderly universe got this way by chance. In this chapter, she uses the social order of bees to illustrate several important points.

Up to Chapter Ten, Dr. Gaydos has taken us step by step from elemental particles to successively more complicated systems. For example, elemental particles combine to form atoms, which combine to form molecules. This combining continues: complex molecules, organic acids, organic proteins, cells, organs, body systems, man (she also discusses the inorganic progressions, including crystals). Each member of each system subordinates its will to the system (just as bees submit to the will of the hive). This all congeals in the Chapter Ten discussion of internal control.

With Chapter Eleven, Dr. Gaydos moves into discussing cancer in terms of the concepts she provided in the preceding ten chapters. The next several chapters move that discussion forward, as she makes and supports two central ideas:

Cancer cells are not invaders (as are viruses), but are the body's own cells that the body has ceased to control. Therefore, it is logical that they will cease to be cancerous if this control can be reasserted. Cancer is a genetic disorder, not a viral or bacterial one.

AIDS, like cancer, is a genetic disorder and therefore requires a genetic cure. The evidence supports the conclusion that AIDS is a disorder of the DNA. There's no reason for human DNAs to succumb to an AIDS attack, because human DNAs have a more powerful organization, are acting in their own territory (the human body), and are being helped by the accumulated inductive control of the organism.
Dr. Gaydos brings some interesting facts to bear in her arguments supporting these central ideas and other conclusions. Consider, for example, her mathematical analysis of the relative energy and information levels of errant DNA versus normal DNA. In that discussion, she makes us wonder, "Trillions of healthy DNAs, and one DNA goes amok? How can that one DNA overwhelm all of the others?" She provides some insights to help answer these and other questions.

In Chapter Fifteen, Dr. Gaydos brings us back around to her earlier discussions of the intelligence of matter (at various levels of succession and stages of evolution), decision-making, the structure of things, how the universe manages information. In Chapter Sixteen, she then makes the case for addressing problems in these very areas as the causes of cancer and AIDS.

She proposes that there are opportunity costs (not her wording) involved in sinking all of our efforts into the traditional "burn you, poison you, cut you" protocols that don't cure either disease. She proposes that we use some resources to develop instrumentation that can be used to pursue a genetic cure. That cure would consist of voluntary control over the genetic machinery.

One of the startling facts Dr. Gaydos presents in her "it really is possible" arguments is the documented experiment in which a person controlled one brain cell (there are 10 billion cells in the brain), using clinical feedback. She provides a reference for this, so the skeptical reader is free to investigate the veracity. Dr. Gaydos presents other startling facts, as well. Many of our common notions about our limitations are simply wrong.

Dr. Gaydos makes a compelling case that it's time to set some of those notions aside. She closes with a plea for government and private funding. We already have a $9 trillion debt that is growing by over half a billion dollars a day and a tax load that stretches the very meaning of "obscene." The USA spends more on its military than the next nine nations combined. What if we spent only as much as the next eight nations combined and used the leftover funds to facilitate this research? Don't hold your breath; the pharmaceutical industry, which would naturally oppose this research, has two full-time lobbyists for each member of Congress. The money will come from the private sector if it comes from anywhere.

I give this book my "must read" rating and label it a keeper.


A note on the language "bumps" in this work

Dr. Gaydos' ideas flow very well from her chemist mind. But if you're not used to authors whose native language is something other than English, the way she says some things will sound strange. Dr. Gaydos, while now living in the USA, is from Spain and spent considerable time in Italy.

As a manager in an international company (Mindconnection, LLC), I work with people all over the world. As an American, my knowledge of other languages is poor (I can dabble in half a dozen, but am fluent only in English). Using an electronic translator helps, but people in other countries carry most of the translation load by speaking English. When they do, I notice little things like the missing articles (e.g., "the") or word variations that are logical but incorrect. You will notice such things when reading this book.

But, let's take this in context. Give a random sampling of American authors a test of Standard Written English (American, not Oxford), and most will fail. An example is John Grisham, a wildly successful author. While Grisham does tell a good story, he doesn't tell it in good English. To the typical American ear, the errors go unnoticed because those particular errors are so ubiquitous as to be normal.

In the nearly 400 pages of this work by Dr. Gaydos, there is not a single misplaced modifier or a single sentence of parallel construction. Few American-born authors can say that about their books.

To counter Stephen J. Synders review of someone he does'nt know.
I know Maria Costell for over ten years, and her methods of trying to raise funds for research may not be the most popular to some.She dose'nt know a great deal about marketing ideas to raise funds.Doctor Gaydos does work nearly all day, who is 80 years old, and tries her best to translate her research from her native speaking language of spanish into english.And lastly Stephen J. Synder is NOT an editor, and reviewer of medical research books.

Wish I could use a zero for possible monetary con as well as quackery if I could
First, the possible monetary con. The author attempted to solicit money from me, or at the least my help in getting money, which I suspect to be part of a potential con.

I quote from selections from her e-mail to me:

"Dear Stephen:
Here attached an Article about the book The Theory of Natural Systems (Amazon Books). Hope it will be of interest to you as well as the book. ...

We are in need of very limited but urgent funds - loans or grants - for two purposes:

Best wishes, Maria Gaydos"

I don't know Ms. Gaydos from Eve, so I'm highly suspicious.

Second, as far as the blurb on this webpage, a degree in industrial chemistry is a long way away from one in molecular biology. And other language in the blurb, and her solicitation of me, sounds very New Age/"metaphysical."

Hence the "quackery" part of my review.

Run like hell from this book.

exploring new ideas
Comments of Eleanor Renn,(retired) former tissue-culture technologist in Diabetes research at the University of Illinois College of Medicine in Chicago


THE THEORY OF NATURAL SYSTEMS.

This is a book that anyone who questions the essence of reality must read. Is reality that which is tangible, accessible only to our five senses? We know from daily experiences that is too limited a view of reality. We treasure the value of abstractions like love, loyalty, honesty, integrity, courage. But to what extend do we ponder the ramifications of this astonishing mental leap into the world of intangibles?
Maria Gaydos brilliantly explores this other side of reality and she does so as a practical scientist not as a poetic, metaphysical dreamer. The author, who has a doctorate in Industrial Chemistry, maintains that matter-energy at its most basic level has the ability to make decisions and generate meaning from information, i.e, has intelligence! "The power to decide is the ultimate variable of physical reality." Just as quantum physics has done, this view challenges the deterministic, mechanical Newtonian view of the world. Bur Dr. Gaydos goes beyond a Niels Bohr interpretation of reality as a statistical cloud of probability. She claims that sub-atomic wave-particles can "decide" to isolate themselves from statistics whether we observe them or not. They can extract meaning out of data, a feat commonly believed reserved for higher forms of matter. A revolutionary idea! But there is more to shock some readers- that elemental matter has a "social" drive to form associations by meaningful relationships which implies a "purpose" (evolution). For those who have hard time reconciling the concept of evolution in a world dominated by entropy Dr. Gaydos provides some thoughtful insights. A quantitative approach to matter-energy leads to entropy (disorder, randomness) but a qualitative approachleads to order and complexity and evolvement of intelligence. That distinction is crucial. The author considers evolution the norm of natural systems, entropy the norm of artificial ones. Unassociated matter is "simply expressing its freedom of decision", the more powerful force governing matter-energy and systems.
The author goes on to examine the role of the will in guiding our experiences. She embraces the whole biofeedback concept for maintaining robust health but at the genetic level. The highest level of energy of the biosystem is the will which evolves from the energetic interrelations of DNAs: "pattern-control". By conscious conditioning of this "pattern-control", we can give "social" guidance to our DNA!
The complexity of this book defies an easy synopsis, whether you agree with the ideas or not the reading of it is a stimulating intellectual adventure. Treat yourself to the fun of exploring new ideas. I give the book four stars.

The Theory of Natural Systems: a New Philosophical Approach
The basic thesis of thebookof Maria Gaydos is that the understanding of living matter within the framework of (I would add the attribute 'recent day') physics is impossible.

Thepostulates of thetheory of natural systems are following. Every system haspower to decide: life is not an outcome ofmere chance and necessity but has evolvedthrough choices and intentional actions.Every system can make meaning out of information andnatural intelligence and information differ from their synthetic counterparts realized in computers. Every system has identity and does not reduce to a mere sum of its parts, and there is a relation between the components of system making them to behave differently asparts of a system and as individuals.Furthermore, even elementary matter has social drive to inter-relate.

These postulates meana dramatic deviation from the basic materialistic and reductionisticdogmas of recent day biology. Personally I would share most of thepostulates as almost such but woulddisagreewith author about the necessity of giving up the idea about laws of Nature. I believe that the laws of nature make sense and are consistent with partially free power of decision but certainly not in the conceptual framework of therecent day establishmentphysics which is only a pale shadow of what is evolving at the frontiers.


The authordevelops her vision very clearly with a strong emphasis on the conceptual basis andat the same time representsa concrete overall view about bio-systems and their evolution. For instance, I liked very much the examples about systems at the borderline of living and non-living matter. Theuse of non-trivial concrete examples makes the book enjoyable reading for both professional andlayman.The author applies this conceptual framework to cancer and aids.The main message is that voluntary control of DNA, demonstrated to be possible even at single neuron level,makes possible self healing via genetic feedback. I would recommend the book to anyone interested in deep questions of life sciences and wanting to know what is happening in the frontline of biology. ... Read more

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A short overview of genes and disease.This article looks at various cancers. ... Read more

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Primary liver cancer is the third most deadly and fifth most common cancer worldwide (~500,000 deaths annually), with a sharp increase of incidence in the United States in recent years. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC) are the major types of primary liver cancer. Risk factors include gender, hepatitis B virus (HBV), hepatitis C virus (HCV), cirrhosis, metabolism diseases, diabetes, obesity, toxins, excess alcohol consumption and smoking. Liver cancer arises most frequently in inflammatory livers with extensive oxidative stress due to viral hepatitis which causes over 80% of HCC cases worldwide. Currently, survival remains dismal for most HCC and CC patients, largely due to the tumor’s aggressiveness at the time of diagnosis and the lack of effective therapy.

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An integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following a systems biology approach, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including Ritux an, Erbitux, Gleevec Herceptin, Avastin, ABX-EGF, Velcade, Kepivance, Iressa, Tarceva, and Zevalin are addressed. Highlights include cancer genomics, pharmacogenomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation. ... Read more

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Thorough Review of Genomics-Based Cancer Research
This work draws on the experience of dozens of leading scientists in the public and private sector in their efforts to use information from genomics to understand and develop cancer therapies.A wide variety of experimental cancer drugs are discussed, and clinical trial data are presented.At 750 pages it is a substantial work, with enough technical detail to suit the bench scientist and physician, yet an easy enough read to be appreciated by the avid learner. ... Read more

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In this groundbreaking work, Dr. Pier Mario Biava argues that the problem with cancer is not the disease itself, but how to treat it, how to approach the affected body. Malfunctioning cells, he says, need not always be cut out or chemically destroyed: they can be reprogrammed for normal functioning. This process involves identifying the information that stem cells receive during embryonic growth in the mother’s womb and reapplying it to cancer cells in the fully developed organism. Thus cancer cells can shift from multiplying and damaging tissue to healthy growth within the organism. Dr. Biava’s dramatic story recounts not only how he came by his key insight but also how he devoted years to its testing and making it operational.

Cancer and the Search for Lost Meaning also contains fascinating conclusions about what the lessons of this work can offer in terms of how we view human life and existence. The book makes a powerful case that cancer is a by-product of the sense of loss and lack of meaning in modern society and that healing cancer involves healing that sense of meaninglessness—a process that can lead to a deeper understanding of, and connection to, life. ... Read more

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Refreshingly different approach to battling cancer...
I have lost a number of friends to cancer, and nearly all of them chose the traditional cancer treatment - namely, cut out the cancer, radiation, chemo therapy, etc.Naturally I am interested in alternative cancer treatment, since the traditional did not work for my friends.I was intrigued by this book.
Biava approaches cancer in a different way.Instead of destroying the cancer, why not re-program the cancer cells - training them to operate in a different way?He claims that this is already done in a human embryo; there is a built in 'life protection' mechanism that often re-differentiates cancer cells before they can do any harm.He acknowledges that the research is still ongoing, but it is very promising.
I have to admit that I had to re-read some portions before I understood them.This book has some complicated medical explanations.But Biava has a friendly style.His writing has a 'ring of truth' that is refreshing in this propaganda-filled world. ... Read more

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This Recent Results in Cancer Research volume contains the majority of the invited expert contributions of the Fifth International Conference on Cancer Prevention, held 6–8 March 2008 at the University of St. Gallen, Switzerland. Written by some of the world’s leading experts in the field, the volume constitutes a comprehensive update on the most important and recent developments in molecular biology and cancer genetics, regarding chiefly the upsurging, but still controversial, field of primary prevention, especially chemoprevention. This conference primarily addressed the four leading and most frequent solid tumor types - breast, colon, gynecological, and lung cancer - all of which demonstrate how such an approach is currently possible and important in clinical cancer prevention research. The future prospects of chemoprevention and the process of selecting the most successful target populations at risk are discussed.

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The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. ... Read more