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Limiting genome replication to once per cell cycle is vital for maintaining genome stability. Although polyploidization is of physiologically importance for several specialized cell types, inappropriate polyploidization is believed to promote aneuploidy and transformation. A growing body of evidence indicates that the surveillance mechanisms that prevent polyploidization are frequently perturbed in cancers. Progress in the past several years has unraveled some of the underlying principles that maintain genome stability. This book brings together leaders of the field to overviewsubjects relating to polyploidization and cancer. ... Read more

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Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer.It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer.Addressing every essential aspect of hereditary breast cancer, this source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer associated with mutations in the BRCA1 and BRCA2 genes. ... Read more

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It has become apparent that the genomes of many organisms are characterized by unique patterns of DNA methylation which can differ from genome segment to genome segment and cell type to cell type. These patterns can be instrumental in determining cell type and function. Thus, it is not surprising that studies on the role of DNA methylation now occupy center stage in many fields of biology and medicine such as developmental biology, genetic imprinting, genetic disease, tumor biology, gene therapy, cloning of organisms and others. Once again, basic research in molecular biology has provided the essential foundation for investigations of biomedical problems.

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This book provides both basic aspects and the latest findings in the molecular and cellular biology of malignant tumors. The focus is on the mechanisms by which normal and neoplastic cells proliferate, differentiate and undergo apoptosis. The differentiation of hemopoietic, epithelial and neuronal cells is treated with respect to growth factors, signal transduction, transcription factors, and genes regulating the cell cycle and the commitment to maturation. The role of oncogenes in neoplastic cell growth and cell death is also covered. The book deals with the regulation of globin gene expression by the LCR locus and the mechanisms of RNA stability for iron-binding and other proteins. The induction of differentiation of neoplastic cells as an alternative approach to cancer therapy is discussed. ... Read more

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Based on a workshop of the Roundtable on Environmental Health Sciences, Research, and Medicine. Held May 16-17, 2001. Softcover. ... Read more

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Why This Book?

Previous books have covered risk factors, but now you can learn howthese risks are assembled into a personal profile, and:

Learn why the most popular model for risk assessment can often bethe most misleading.
Realize that women without known risk factors are still at a significant risk for developing breast cancer.
Understand how important your personal risk profile becomes whenyou begin to make other health care decisions.
Appreciate how media-supported studies of risk factors frequentlybecome distorted.
Discover that there are protective factors that can offset risk factors, as well as the option of chemoprevention.
Gaze into a crystal ball and visulaize the future of risk assessment. ... Read more

Customer Reviews (2)

You Won't Find This Information Elsewhere
I bought this book because of Dr. Hollingsworth's reputation as a physician and a communicator; I am recommending it because everyone, at some time in her life, will want more information concerning her own... or a loved one's... breast cancer risk. There is good news: It is largely quantifiable.

"My mother has been diagnosed with breast cancer; am I at increased risk? What about my (daughter/sister) ?"

"I am at higher risk of developing breast cancer; what can I do to increase my chances of surviving this disease?"

These are tough questions which until now have too often gone unanswered.

Even if your own identifiable breast cancer risk is minimal, the odds are that you will have a friend or loved one who will be forced to deal with this issue. Given the existing lack of unanimity within the medical community as to even the diagnosis & treatment of breast cancer, it is not surprising that we are faced with such conflicting information about our risk of developing the disease. Highly-touted statistics notwithstanding, there is NO one-size-fits-all answer. When your health is at stake, statistical tautologies are not helpful.

Dr. Hollingsworth's book is written for clinicians as well as lay people. It explains in understandable language what you need to know to make the right choices. This book arms the reader with the knowledge to ask the right questions & the confidence to seek the best alternatives for her own unique situation.

There is a peace of mind to be gained from reading Dr. Hollingsworth's book. It places the mysteries, fables, facts & options re: risk assessment in clear perspective. It answers the question, "What on earth do I do now! "

Once you have read this book, I suspect that you will want to give copies to all the important women in your life.

The Truth is Out There
Dealing with breast cancer or the threat of it has been a way of life in our family.Both my aunts and mother have struggled with this disease.It claimed the lives of my aunts and my mother has one of those incredibly high individual risk assessments that cause us all to pause when it her exam time rolls around.

Whether medical journals or Ladies Home Journal, if it involves breast cancer, breast imaging, breast cancer dectection or treatment, I consume the information with a voracious appitite.Unfortunately, not all of it is worth filtering through but every now and then you hit pay-dirt.

Very recently that happened and would encourage others interested in the subject of breast cancer to read the new book "The Truth About Breast Cancer Risk Assessment", by Alan B. Hollingsworth, M.D.If you have ever wondered about all the data which comes flooding out of breast cancer studies which seem to contradict themselves, or you have been tempted to believe detecting (much less treating) breast cancer can be taught by using the cookie cutter method then this is a must read.

Although the book is crammed full of numbers and rather abstract mathmatical concepts, the reader quickly gains a sense of the deeper underlying message that like the X-Files - the truth is out there BUT you must realize that what you first encounter or are led to believe as true,may not be.

This book is a dose of reality in a world which is far too often looking for a quick a fix and sound bite for the 6 o'clock news about some revolutionary breakthrough in breast cancer which may or may not really be significant.

I consider myself a student on this topic and try to learn as much as I can.Anyone interested in the subject of breast cancer should read this book.You will have a completely new set of skills to filter the data you encounter from this point on. ... Read more

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This book reviews both genetic and biochemical data on the origin of genome instability and its impact on carcinogenesis. Reflecting recent discoveries and ongoing research, it discusses DNA repair mechanisms and hereditary cancer syndromes, as well as checkpoint mechanisms operating to safeguard chromosome integrity during cell cycle progression. Moreover, it summarises our current understanding of the various defects that may allow cancer cells to rapidly accumulate critical mutations and evolve, through processes reminiscent of Darwinian selection, an increasingly aggressive behaviour. Hopefully, this book will stimulate thought, discussion and experimentation, and serve as a rich source of information for a wide audience, including advanced students, researchers and clinical oncologists.

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Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics, including platelet-derived growth factor in disease, genetic predisposition in tumor development, primary effusion lymphoma, and many more.

Cancer is not one disease, but a group of diseases in which malignant cells grow out of control and spread to other parts of the body. Eventually these cells form a visible mass or tumor. Appropriate treatment for cancer depends on what kind of cancer a person has. The type of cancer is determined by the organ the cancer starts in, the kind of cell from which it is derived, and the appearance of the cancer cells. ... Read more

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The Advances in Cancer Research series provides invaluable information on the exciting and fast-moving field of cancer research. This volume presents outstanding and original reviews on a variety of topics including Central Roles of Mg2+ and MgATP2- in the Regulation of Protein Synthesis and Cell Proliferation: Significance for Neoplastic Transformation; Presence and Influence of Human Papillomaviruses (HPV) in Tonsillar Cancer; T-Cell Transformation and Oncogenesis by ã2-Herpesviruses; Chaperoning Antigen Presentation by MHC Class II Molecules and Their Role in Oncogenesis; Soluble Mediators of Inflammation During Tumor Development; Classical and Non-Classical HLA Class I Antigen and NK Cell Activating Ligand Changes in Malignant Cells:Current Challenges and Future Directions. ... Read more

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During the past decade enormous progress has been made in our understanding of the molecular genetic basis of many oncologic disorders, and such information is already beginning to impact on clinical practice. This book provides oncologists with a concise summary of what is presently known about the genetic basis of monogenic and polygenic oncologic disorders. The glossary provides a thorough grounding in the fundamentals of genetic terminology and techniques. With its quick reference format, Genetics for Oncologists will be readily appreciated by busy practitioners. ... Read more

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Third author, Terry F. Davies, is with Mount Sinai School of Medicine, New York, NY. Papers collected at the first International Symposium on the Genetics of Complex Thyroid Diseases, held in Kyoto, Japan in association with the International Thyroid Congress, in October 2000. ... Read more

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This book covers all the relevant aspects of communication in cancer care, such as communication in cancer prevention and genetic counselling, communication at different stages of disease and communication with the family and children. In addition, more general topics are discussed, such as the benefits and evidence of communication skills training and the challenges of interdisciplinary and cross-cultural communication. Besides useful information on direct clinical relevance, current theoretical frameworks and research on communication in oncology are presented. The chapters are written by leading figures in the field of psycho-oncology and communication, who work and teach in different European countries.

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Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.
Volume 39 of Advances in Genetics completes the trilogy of volumes authored by Dr. Igor Zhimulev of the Institute of Cytology and Genetics in Novosibirsk, Russia. This set comprises what is perhaps the most comprehensive collection of volumes dedicated to the study of polytene chromosomes. Volume 39 picks up where the previous two volumes, 34 and 37, left off. It covers the organization of genetic material in the morphological structures of the interphase chromosome, the chromomeres and the interchromomeric regions, and the structural changes occurring during the activation of the chomomeres, the puffs. ... Read more

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Breast cancer is a malignant tumour that has developed from cells of the breast. A malignant tumour is a group of cancer cells that may invade surrounding tissues or spread (metastasize) to distant areas of the body. The disease occurs almost entirely in women, but men can get it as well. The main types of breast cancer are ductal carcinoma in situ, invasive ductal carcinoma, lobular carcinoma in situ, invasive lobular carcinoma, medullary carcinoma, and Paget's disease of the nipple. About 1 of 8 women will get it in her lifetime. This new book presents state-of-the-art research in this fast-moving field. ... Read more

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Different cancer types can result from a multiplicity of genetic and environmental factors. In recent years a number of genes have been identified as strong determinants for particular forms of cancer (particularly colon and breast cancer). The incomplete penetrance often evinced by the mutations of these genes has raised the possibility that additional endogenous or exogenous determinants contribute to cancer development or suppression. The major aim of this book is to present an integrated view of the various environmental, epidemiological and genetic determinants that contribute to a disease syndrome collectively known as "cancer". ... Read more

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The pioneering work of a few investigators in the 1960s made it clear that genetic factors play an important role in tumor development. Hereditary factors have nonetheless received far less attention than environmental ones in the study of the causes of cancer. This has resulted in the discrepancy that there is a strong general concern, for example, about cigarette smoking and alcohol abuse (the two most common causes of cancer in humans) yet that many physicians give little or no attention to the patient's familial history and that first-degree relatives of patients are rarely felt to be at risk because of the common genetic background. This volume focuses on the genetic features of most human tumors, emphasizing their familial and hereditary basis as well as the close interaction between environmental and genetic factors. The aim is to translate our increased knowledge of familial cancer into new programs for cancer prevention and detection, such as the surveillance of high-risk individuals. ... Read more

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Genes interact with environment, experience, and the biology of the brain to shape an animal's behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity.

* Explores latest topics in neural circuits and behavior research in zebrafish, drosophila, c.elegans, and mouse models

* Includes methods for testing with ethical, legal, and social implications

* Critically analyzes prospects future prospects ... Read more

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The Advanced Text series is designed for students taking advanced-level courses, including upper-level undergraduates and graduate students. Titles in this series will also be invaluable to researchers new to a field, and to established researchers as a basic reference text.

Molecular Biology of Cancer, Second Edition is now in a larger format that has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer. ... Read more