Product Description
In recent years, the molecular analysis of chromosome 21 has progressed so rapidly that the current level of sophistication in understanding the organization of its genes and DNA sequences perhaps exceeds that of any other chromosome. This book explores the fundamental nature of this condition's pathology as related to the structure and expression of genes that are known to be critical in the development of Down Syndrome. It recounts the impressive advances made toward a complete physical mapping of chromosome 21. It also discusses how individual genes in this chromosome have been isolated and their effects relevant to aspects of Down Syndrome are being studied in both cellular and in vivo models. This text provides a comprehensive account of the most up-to-date research in this area, and offers a general overview of the advances in molecular analysis techniques that are revolutionizing the entire field of chromosomal mapping. ... Read more

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This book presents the latest research on speech and language development and relevant assessment and intervention for individuals who have Fragile X Syndrome (FXS) or Down Syndrome (DS). The book reviews the current state of knowledge on both syndromes across the lifespan. ... Read more

Customer Reviews (1)

An essential and invaluable contribution
Every child, regardless of the degree of their developmental disabilities, is entitled by federal law to the best education they can benefit from. This holds especially true with respect to their ability to communicate with others. The impressively collaborative work of Joanne E. Roberts, Robin S. Chapman, and Steven F. Warren in compiling contributions from twenty leading experts and specialists in this field, "Speech & Language Development & Intervention In Down Syndrome & Fragile X Syndrome" is the newest addition to the 'Communication and Language Intervention' series from the Paul H. Brookes Publishing Company. Presenting an advanced body of work for aspiring and practicing professionals, "Speech & Language Development & Intervention In Down Syndrome & Fragile X Syndrome" presents cutting edge research and clinical insights into the behaviors, characteristics and genetics associated with these two genetically-based conditions; explains how speech and language develop across the life span of human beings; identifies for application the principles of effective assessment with members of every age group; demonstrate specific interventions that support speech and language development; show how to tailor assessment and intervention to individual needs and abilities; illustrate the application of assessment and intervention techniques that can be utilized with other disabilities such as autism; and underscores the necessity and value of family involvement in education and treatment approaches. "Speech & Language Development & Intervention In Down Syndrome & Fragile X Syndrome" is an essential and invaluable contribution to professional and academic library Speech-Language Pathology and Developmental Disabilities reference collections and supplemental reading lists. ... Read more

Product Description
(Whurr Publishers) Papers presented at the Sixth World Congress on Down Syndrome held in Madrid, Spain, in October 1997. Focuses on scientific advances and therapeutic practices. Discusses independence, education, psychology, communication, medicine, genetics, and Down syndrome in the world. For clinicians. Softcover. ... Read more

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Progress in Clinical and Biological Research, Volume 384 The Phenotypic Mapping of Down Syndrome and Other Aneuploid Conditions Proceedings of a National Down Syndrome Society Conference Held in New York, January 14 and 15, 1993 Charles J. Epstein, Editor In the last decade, considerable progress in the phenotypic mapping of Down syndrome and other syndromes caused by aneuploidy has been made, answering many perplexing questions and raising new ones. Of primary concern is the relationship between the individual components of the Down syndrome phenotype and the specific genes that give rise to them. In its continuing role of supporting basic research through scientific conferences, the National Down Syndrome Society brought together a panel of experts from genetics, molecular, and cellular biology to explore the genotype—phenotype correlations of Down syndrome and other aneuploid conditions. The Phenotypic Mapping of Down Syndrome and Other Aneuploid Conditions discusses approaches to understanding the genetics and the underlying mechanisms of the different phenotypic characteristics of Down syndrome, as well as animal models of trisomy 21 relevant to phenotypic mapping of Down syndrome. Since the precedents for phenotypic mapping go far beyond human chromosome 21, the book also covers several other aneuploid states in addition to Down syndrome itself, thereby presenting the latest information about state-of-the-art approaches to phenotypic mapping. The text is divided into the following sections:

• General Approach to Phenotypic Mapping in Aneuploidy
• Phenotypic Mapping of Down Syndrome
• Phenotypic Mapping of Animal Models
• Phenotypic Mapping in Conditions Other than Trisomy 21

Product Description
Findings and reviews by foremost experts offer a comprehensive survey regarding the present state of our understanding of the development of Alzheimer disease in people with Down Syndrome and the relationship between these disorders. Coverage includes many processes involved in the pathogenesis of Alzheimer disease, the latest molecular and cellular techniques for defining these processes, the usefulness of animal model systems for studying normal and abnormal development and function of the central nervous system, the relationship between chromosome 21 and Alzheimer disease and much more. ... Read more

Product Description
Expanding the scope and depth of the classic The Young Person with Down Syndrome, the authors haveincorporated significant scientific advances into their new volume on the issues that adolescents with thisdisability face. Written for health care professionals, psychologists, other developmental disabilitiespractitioners, educators, and parents, it covers biomedical concerns; behavioral, psychological, andpsychiatric challenges; and education, employment, recreation, community, and legal concerns.Contributions from leading experts lend experience and perspective to this multidisciplinary resource. ... Read more

Customer Reviews (1)

Adolescents With Down Syndrome: Toward a More Fulfilling Lif
I decided to read this book for a class I'm taking on the psychology of exceptional children.The book met all of the requirements made by my professor, and was written on a subject that I am very interested in. After reading the book and writing a review for my class, I can say thatthis book is a wonderful book for parents, educators, and professionals toread.I gained so much knowledge about working with adolescents who haveDown syndrome as well as adolescents who do not have disabilities.I amcurrently in college working on my B.A. in special education, and I havefour children.Three of my children are adolescents, and two of them havelearning disabilities.Due to my experience as a parent and a studentmajoring in special education, I can say that I learned more than I thoughtI would just from reading the title of this book. Before I read the book,I thought I would finish school and work with young children who havemental retardation, now I know that I want to work with children of allages.I would also like to have my home open to individuals who have Downsyndrome and would like to live away from their parents home.I would liketo set up an apartment within my home, so a person with Down syndrome couldlive there and be able to receive help from me if and when they need it. Byreading this book, I now know of so many different ways in which I can helpindividuals with Down syndrome.I am very excited to get started with mycareer, but more than that, I am ready to be involved in the lives ofindividuals who have Down syndrome.I checked this book out from thelibrary, but I want to buy it for myself, so I can go back to it as areference when I need it.I encourage anyone who is interested in workingwith adolescents with Down syndrome, parents who have children with Downsyndrome, educators (both regular and special), and health careprofessionals to read this book.You will be glad that you took the timeto find out more about these special individuals. ... Read more

Product Description
This book contains updated reviews and original research work on Down Syndrome focussing on brandnew results in neurobiology, in particular results on gene hunting (subtractive hybridization, differential display) and neurochemistry. The book provides new data such as a subtractive library of Down Syndrome brain showing cDNAs that are overexpressed or downregulated and can be regarded as a source for further research on the preliminary transcriptional data given. A 2D-electrophoretic map of human brain proteins including Down Syndrome brain protein expression established by in-gel-digestion of spots with subsequent MALDI-identification provides the scientific basis for protein work to the neuroscientist. Altogether, the book provides a series of new candidate genes possibly involved in Down Syndrome neurobiology, tools for neuroscience studies on Down Syndrome brain thus serving as a manual and updated views and aspects on Down Syndrome pathobiology. ... Read more

Customer Reviews (1)

the molecular biology of Down syndrome
It is impossible to review this book as it has not yet arrived. This book and a number of other books I ordered have not arrived. Two thirds of my order arrived 2 weeks ago and I am still waiting for the other books. Given that I have been invited to review the book does this mean that you assume that I have received this book? Mmmmm....I know that Amazon.com is hermeneutically sealed and all customer service is computer automated. I have always wondered what redress I would have is an expensive order goes missing. Guess I am about to find out and I don't feel optimistic. ... Read more

Product Description
This volume is devoted to the health care of people with Down's Syndrome throughout their lives, from childhood to old age. It examines current advances in research and medicine that allow patients to live longer and healthier lives and to participate more fully in community life. ... Read more

Product Description

Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come by—until now. The “Gale Encyclopedia of Genetic Disorders” addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the “Gale Encyclopedia of Genetic Disorders” for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.

Product Description

Information on many genetic disorders, and the frequent new findings on them, has been extremely difficult to come by—until now. The “Gale Encyclopedia of Genetic Disorders” addresses the need for current, hard-to-find facts on emerging discoveries. The two-volume Encyclopedia, presented in a single alphabetical sequence, provides clear, complete information on genetic disorders, including conditions, tests, procedures, treatments and therapies, in articles that are both comprehensive and easy to understand, in language accessible to laypersons. The articles are arranged in a standardized format for quick comparison and ease of use, while non-disorder topics are covered in detail with extended entries. Students will want to consult the “Gale Encyclopedia of Genetic Disorders” for useful information on a range of well known disorders, including Down Syndrome, Trisomy, Hemophilia and Tourette Syndrome, and rarely seen diseases such as Meckel Syndrome, Neuraminidase Deficiency and Phenylketonuria.

Product Description
This digital document is an article from Emerging Infectious Diseases, published by U.S. National Center for Infectious Diseases on August 1, 2010. The length of the article is 2072 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Pandemic (H1N1) 2009 virus and Down syndrome patients.(DISPATCHES)
Author: Rogelio Perez-Padilla
Publication: Emerging Infectious Diseases (Magazine/Journal)
Date: August 1, 2010
Publisher: U.S. National Center for Infectious Diseases
Volume: 16Issue: 8Page: 1312(3)

Distributed by Gale, a part of Cengage Learning ... Read more

Product Description
The story of Matthew begins in the labor room. There are questions about whether he is "okay" as he is only four pounds, ten ounces, and his skin color was unusually red. It isn't until the next day, that the suspicions are realized when a doctor tells the parents he suspects Matthew has Down syndrome.

What follows is an anguish that only a parent who has been through this would understand. The process of grieving for the loss of a normal child is followed day by day until the determination to make things right takes the place of guilt, sadness and anger. Matthew's mother goes through a process of teaching that encompassed every day, and in the end good results came out of it all, even though the doctors gave little hope for Matthew learning or being able to take care of himself. Her methods are outlined in the story, which included mountains of word cards and a constant flow of stimulation. He was reading his first few words at three years old and by the time he was ten he was playing the piano and now at seventeen his musical talents have grown whereas he is also playing the harmonica, xylophone and guitar. He has performed publicly dozens of times and is sought after regularly to appear in community events. ... Read more

Product Description

The “Gale Encyclopedia of Science” is written at a level somewhere between the introductory sources and the highly technical texts currently available. This six-volume set covers all major areas of science and engineering, as well as mathematics and the medical and health sciences, while providing a comprehensive overview of current scientific knowledge and technology. Alphabetically arranged entries provide a user-friendly format that makes the broad scope of information easy to access and decipher. Entries typically describe scientific concepts, provide overviews of scientific areas and, in some cases, define terms.

Product Description
Presents a series of papers reporting on recent progress in understanding key genetic, molecular and cellular mechanisms behind differentiation and morphogenesis associated with trisomy 21. Also offers an examination of the condition's physical phenotype and its anatomical manifestations. ... Read more

Product Description
Providing a comprehensive survey of the clinical, educational, developmental, psychosocial, and transitional issues relevant to people with Down syndrome, this book addresses the needs of family members, caregivers, and professionals alike. Edited in association with the National Down Syndrome Society, this up-to-date treatment incorporates the newest developments concerning sexuality, inclusion, transition into adulthood, and legislation, as well as a discussion
of the Human Genome Project and the sequencing of chromosome 21. ... Read more

Customer Reviews (7)

Stunning vision of the next century of research
The case of down syndrome is one that is complex yet simple, and challenging yet easy. To understand the complexities that must occur to result in an affected patient is beyond most human comprehension. This book does a great job at highlighting the past milestones in research, yet focusing primarily on the future of study in this subject. Bill optomistically creates a nurturing sense of hope in all patients currently affected by this raveging disease, and instills hope for a better life, living life to the fullest

Useful Reference
"...a useful reference tool for families and service providers." (Human Genetics)

Terrific Compendium
"...a terrific compendium of the wide array of topics...whatever the challenges that lie ahead...we are much better prepared by the information and vision provided by this excellent book." (Archives of Pediatrics and Adolescent Medicine, May 2003)

"Exceedingly Valuable"
"...exceedingly valuable for a wide spectrum of individuals: parents, professionals, caregivers, and researchers..." (American Journal of Human Genetics, Vol. 72, 2003)

Recommended Book
"I...consider a copy of this book a must for every institutional and personal library." (Journal of the National Medical Association, March 2003) ... Read more

Product Description

Advances in Down Syndrome Research represents updated research in several areas of Down Syndrome (DS). A new promising animal model of DS is reported, and this opens new opportunities to study pathomechanisms and pharmacological approaches as it is more than difficult to carry out studies in humans and the clinical features are highly variable. In terms of biology, cell cycle and stem cell studies and in terms of biochemistry, relevance of studies on a specific protein kinase, channels, transporters, superoxide dismutase, antioxidant system, chromosome assembly factor and other important biological structures are provided. And again, the gene dosage hypothesis is addressed and although the vast majority of chromosome 21 gene products is unchanged in fetal DS brain, a few specific chromosome 21 encoded structures including transcription factors are indeed overexpressed, although findings in fetal DS are different from those in adult DS brain, where Alzheimer-like neuropathology supervenes. ... Read more

Product Description
Many parents of children with Down syndrome would like to help their child improve nutrition and manage weight, but don't know where to begin.Now, this much-needed book looks at all aspects of nutrition and healthy living for children with Down syndrome, from birth through young adulthood. The author, a mother of a child with Down syndrome and a registered dietitian, encourages parents to start teaching healthy habits early but stresses that it's never too late to start, no matter what age. Based on years of personal and professional experience and supported by the latest medical research and insights from other parents and adults with Down syndrome, chapters cover:

Breast and bottle feeding

Basic nutrition and physiology

Celiac disease

Diabetes

Alternative therapies

Food and school

Weight management

Fitness and exercise

Cooking and menu planning

Education activities

The appendices contain cookbook lists, information on calculating calorie needs, and more.Resource and reading lists round out this practical, comprehensive guide.

With this handbook, parents, dietitians, and therapists will understand the connection between Down syndrome, diet, and nutrition, and be in a better position to guide children toward a healthier future. ... Read more

Customer Reviews (8)

The Down Syndrome Nutrition Handbook
The book was very informative for families starting out with a young down syndrome child.The information was easy to follow and "do-able".I would recommend it highly to these families.Unfortunately, the information we needed was for anoverweight adult with down syndrome.I have not found any books that deal with nutrition issues in adults with down syndrome. As with most books, we will use the information and try to adapt it to our situation.

Excellent Information
I wish that I had had this book when my teenage daughter was a newborn.I am trying to undo the poor choices made along the way in her nutrition in order to maximize her health and physical well being.This book has been tremendously helpful.

The Down Syndrome Nutrition Handbook: A Guide to Promoting Healthy Lifestyles
Very good book
Easy to read
Very informative for parents with and without medical knowledge
Have found it very useful as a guide to my daughters nutritional needs and abilities

Geat Book
Don't let the long (boring) name fool you, it is a GREAT book! As our daughter is getting older (she is 16,) she is taking control of her diet.I can't be with her all the time, so I have to teach her to eat healthy.This might sound simple, but it isn't.Well meaning relatives offer her foods she shouldn't eat, and others don't know that she has some 'nutritional issues,' like Celiac Disease.Our daughter has to know what she can and can't eat, as well as portion control. The DSNH not only has information for me as a parent, but it has worksheets and teaching activities for our daughter to help her learn healthy eating habits and good fitness activities.Did I say that it is a GREAT book?We copy off the worksheets and post them on the fridge, so our daughter can track what she eats during the day to make sure that she has 'hit' at the necessary food groups and water intake goals.She even has her fitness goals for the week.

The book covers nutritional information and needs from birth through adulthood.Section three is the one that we are working on right now: Teaching Healthy Choices to Encourage Healthy Lifestyles.It has everything from menu planning, to cooking and fitness.It's full of readable and understandable information for me and hands on learning for our daughter.That is a great combination if you ask me!

Our daughter will be the one in control of her own cooking, fitness activities and health in a few years.This book will help me help her to make a smoother transition to become a more independent and healthy adult with Down Syndrome.

Good for the average person
You don't have to be an expert to understand the concepts in this book. It's written in such a way that the average person can understand the issues and put the tools to work. It tackles every feeding/eating issue that a person with Down Syndrome faces, from birth to adulthood. I strongly recommend this book for anyone who has a family member with Down Syndrome or who works with people with Down Syndrome. ... Read more

Product Description
Dr. Mark Selikowitz, a consultant paediatrician, has drawn on his extensive experience with children with Down syndrome to write this sympathetic and authoritative book, widely regarded as the definitive guide for parents. In this new edition, he looks at the many new opportunities that have appeared over the past few years in the educational, social, and employment spheres for people with Down syndrome. These have been accompanied by favorable changes in community attitudes. A particularly encouraging development is the greater attention paid to the wishes of people with Down syndrome. The book offers advice and reassurance to these people and provides an essential guide to their parents and the many health workers who come in contact with Down syndrome children and adults. ... Read more

Customer Reviews (3)

Buy a different book!!
I read this book yesterday at the library and found the author to be spineless, inhumane and downright mean. This person should have never written this book!!

The beginning of the book explains the many emotions parents, siblings, grandparents etc. may experience when faced with a Down syndrome diagnoses, but the advise given is from the heart of a man who couldn't go into the nursery to see or touch his baby for three days simply because she has DS. An extra chromosome 21 does not render a person unlovable or contagious. The author does assure the reader that love will blossom but it could take some time. There's nothing wrong with that advice but a serious attitude adjustment is in order. I understand not everyone's reactions are the same but a loving heart is a loving heart even if it may be paralyzed for a bit by shock or other emotions.This author's poor daughter needed to be hugged and kissed and cuddled by her dad.Hisactionsshouldn't have beenguided byhis emotions.He should have seen to the baby's needsandlet his emotions catch up withhis obligation to care for his baby.I dealt with my emotions when my son was diagnosed with DS. In my eyes he's the cutest most wonderful baby on the planet as were my other children when they were the babe in my arms.

The book goes on to explain that siblings may have negative feelings toward the sibling with DS. The author suggests that you let the siblings know that they will not be responsible for the care of the sibling with DS after the parents are no longer able to. GRRRR!!Siblings should want to support each other whether they have DS or not.For the brother or sister with DS it may be visiting at an assisted living facility or opening up an extra bedroom.My younger brother was born with DS and we always knew he needed more care and attention than the rest of us.We gave it willing. We were just dealt a different hand than other families.

The author wants parents to help their children deal with taunts about their sibling with DS by allowing the child to take it out on the parents. What?!!! Subtract DS from the equation and see how to deal with taunting and teasing. It's the same situation when DS is added back in.

The book includes the same clinical information about DS as any other book so it's no goldmine of knowledge.

The author explains the prenatal tests available to detect DS. There is a warning about the possibility of a miscarriage but concludes that parents are going to have to decide for themselves if they would terminate the pregnancy if DS is detected. I would have loved to read that the author found such joy in raising a daughter with DS that he encourages parents to see past societies shallowness and love their baby but the author never does.

I know I'm a better person because I had the privilege of being touched by DS.I'm the mother and the sister of wonderful people, two of them have an extra chromosome.

I wish I could impress upon every man, woman and child that DS is not a curse.This book doesn't do anything to bring that wish to fruition.

Positive and informative
Written by an Australian pediatrician, this book is both positive and informative. The book presents a great deal of material but does it in an clear and accessible style . The author is extremely optimistic about the future of people with Down syndrome and this optimism shows in his writing. The material covered includes early childhood development, school, adolescence, and adulthood. Laws in the US, UK, and Australia are covered.

A very good overview
I read this book shortly after my son was born with Down Syndrome.It was not as "mushy" as the Stray-Gunderson book.It has wonderfulinformation on the joys of raising a child with down syndrome, while givingvery specific information on potential health problems and what to be sureyour pediatrician is aware of.I liked the fact that he recomends that theparent is the child's biggest advocate, and that we prepare ourselves forthat role. ... Read more

Product Description
Defective genes are responsible for an estimated 4,000 hereditary disorders. Children inherit these disorders from their parents in many different ways. While biomedical researchers have now identified most genes associated with genetic diseases, there are no absolute cures for these diseases today. Scientific advances have enabled affected people to experience longer and more comfortable lives, because they and their families have more beneficial means of coping with genetic disorders.

This second edition Sourcebook provides new and updated information to help laypeople understand the working of genes, the ethics of gene testing, and the causes and treatments of some of the most common genetic disorders. The book also covers the lifestyle expectations of individuals who suffer with these disorders, their disease management and care, and current research initiatives to prevent and cure gene defects. A glossary of genetic terminology and a directory of resources provide additional support and information. ... Read more

Product Description
This book presents latest original research work and current opinions on Down syndrome, focussing on the molecular biology of the Down syndrome brain at the protein level, rather than at nucleic acid level, as it is the proteins that do the work, and there is a long and unpredictable way from RNA to protein. The studies used fetal brains with Down syndrome in which no neurodegeneration was found and characterized proteins by two-dimensional gel electrophoresis and mass spectrometry. The book provides new aspects, such as that neuronal density and neurotransmission is unchanged in early life but synaptosomal structures and dendritic spines are already seriously affected at the early second trimester. The presentation of a series of tentative mechanisms for the development of the Down syndrome neurophenotype provides models for present and future thinking on the neurobiology of the Down syndrome brain. ... Read more