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Few areas of medicine remain unaffected by the rapid developments in the field of molecular genetics which have taken place in recent years. Not only the classic Mendelian disorders, but also diseases of complex and multifactorial aetiology are now susceptible to investigation at the level of chromosomal DNA sequence. Nevertheless, many clinicians remain baffled by the technical and theoretical issues involved, and uncertain of the implications for their field of practice. The aim of this book is to set out the technology and applications of molecular genetics in those areas of clinical medicine where they have had most impact. The book will provide a much needed source of reference and explanation for students and practitioners in all medical disciplines, who wish to increase their understanding of this subject in a clinical context. Line diagrams and illustrations will be used to fully clarify the principles and practices discussed in the text. ... Read more

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This book focuses on the role of both biological and behavioural factors in the fertility and specific patterns of health and disease of minority populations living in developed and less developed countries. The importance of marriages contracted between close relatives is stressed, as over 900 million people inhabit countries where 20 to 50 per cent of marriages are inbred. Past, present and future trends in population mixing are evaluated, with special consideration of their effects on the health of minorities. The research data is based on the practical experience of the editors and contributors. ... Read more

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This volume should be useful to medical students, graduate biochemistry or genetic students, and researchers alike. This books picks up the first chapter in the new sixth edition of "The Metabolic Basis of Inherited Disease," and offers an overview of human biochemical genetics as it stands now. A new gene map with an alphebetized list of disorders cross referenced by site, and a list of selected readings are included. ... Read more

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High Quality Content by WIKIPEDIA articles! Alternative splicing is a process by which the exons of the RNA produced by transcription of a gene (a primary gene transcript or pre-mRNA) are reconnected in multiple ways during RNA splicing. The resulting different mRNAs may be translated into different protein isoforms; thus, a single gene may code for multiple proteins. Alternative splicing occurs as a normal phenomenon in eukaryotes, where it greatly increases the diversity of proteins that can be encoded by the genome; in humans, over 80% of genes are alternatively spliced. There are numerous modes of alternative splicing observed, of which the most common is exon skipping. In this mode, a particular exon may be included in mRNAs under some conditions or in particular tissues, and omitted from the mRNA in others. The production of alternatively spliced mRNAs is regulated by a system of trans-acting proteins that bind to cis-acting sites on the pre-mRNA itself. Such proteins include splicing activators that promote the usage of a particular splice site, and splicing repressors that reduce the usage of a particular site. ... Read more

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This digital document is an article from UXL Complete Life Science Resource, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 657 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.Features alphabetically arranged entries on theories, concepts, and scientific discoveries and developments pertinent to the study of life science in schools today. Also featured is a chronology of discoveries and a report topic section that suggests a range of research topics and experiement ideas. ... Read more

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This digital document is an article from UXL Encyclopedia of Science, brought to you by Gale®, a part of Cengage Learning, a world leader in e-research and educational publishing for libraries, schools and businesses.The length of the article is 2022 words.The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase.You can view it with any web browser.This collection of entries covers major areas of science including: biology, genetics, microbiology, astronomy, chemistry, physics, engineering, technology, geology, weather, archaeology, psychology, mathematics, and medicine, and provides readers with a wide range of up-to-date, relevant, and accurate information. ... Read more

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This digital document is an article from The Futurist, published by World Future Society on January 1, 2000. The length of the article is 524 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Preventing Genetic Disorders.(Brief Article)
Publication: The Futurist (Magazine/Journal)
Date: January 1, 2000
Publisher: World Future Society
Volume: 34Issue: 1Page: 12

Article Type: Brief Article

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This digital document is an article from Arkansas Business, published by Journal Publishing, Inc. on July 25, 1994. The length of the article is 825 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: UAMS laboratory unravels DNA code, diagnoses genetic disorders and more. (University of Arkansas for Medical Sciences)
Author: George Waldon
Publication: Arkansas Business (Magazine/Journal)
Date: July 25, 1994
Publisher: Journal Publishing, Inc.
Volume: v11Issue: n30Page: pS7(1)

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This book describes the conditions and problems of both children and adults. It considers the day-to-day management of disorders. It is written in non-technical language for a wider audience. Enough detail is given for the medical, nursing and midwifery professions. It is well indexed and has an extensive glossary. ... Read more

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Animal models of chronic renal failure are useful research tools only when the selected model lends itself to providing the answer to a particular question. This book presents a broad spectrum of experimental and genetic rat models of chronic renal failure in such a way that their advantages, disadvantages and special features are clearly indicated. The information provided enables researchers to choose the appropriate model. This is especially important in tne testing of therapeutic modalities. The book not only describes the induction and progression of renal failure, but also discusses factors, intrinsic to each model, which could considerably influence results. In addition, problems in the measurement of blood pressure and glomerular filtration rate are considered in detail. ... Read more

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Ben Gurion Univ. of the Negev, Beersheva, Israel. Explores the new era of study made possible by the pace of discovery and innovation in the field of molecular genetics. Reflects the point of view of the 35 contributors. For students and others interested in evaluating and exploring the relationship between molecular genetics and the human personality. DNLM: Personality Disorders. ... Read more

Customer Reviews (1)

Surprise, surprise!
The authors describe two personalities, "harm avoidance" and "novelty seeker."They, and others, have identified the genes responsible for these traits. I have two grandsons less than a year apart. The oldest when crawling on the floor and came to a step, he would not proceed.The other coming less than a year later simply tumbled over the step. At four and five when I took them to the park, the oldest climbed the slide, thought about it and climbed down. He repeated this several times before sliding down.The other simply climbed up and slid down; then tried to climb up the slide.At the Chinese restaurant the eldest will still only eat white rice. The othergobbles everything.The eldest can not ride a bike, the younger has been struggling to ride before he was big enough. The eldest is not at all interested in a driver's license. The younger got his license as soon as he was old enough to apply.
The eldest can perform solo on the stage, publish the school paper, etc, but he avoids harm.
My father was a "novelty seeker" and so was I and one of my three sons. He started international travel at age 16, when he went to spend a year at school in Turkey. He spent his last college year in India. When he traveled Japan he would stay at Buddhist monasteries. He has become an art historian and leads tours to Burma and India. (Can you imagine what his tours are like?) He recently married a Thai.
I never thought much about this personality correlation till I read this book. It is not too technical and I think you will find some of your friends or some of your children described.
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Hardbound. Designated as the "common diseases," hypertension, diabetes mellitus type 2, obesity, dyslipidemia, arteriosclerosis and gout, are becoming the most important world-wide health problems, requiring intensive research in order to better understand their pathogeneses, and to administer proper preventive measures. This book contains the proceedings of the Uehara Memorial Foundation Symposium 1999, a collection of 29 outstanding contributions from the most eminent experts in the field of genetics and pathogenetics. It is divided into 5 sessions: Adipogenesis and Obesity, Diabetes Mellitus, Hyperlipidemia, Hypertension and General Molecular Biology in Common Disease.

Common Disease: Genetic and Pathogenetic Aspects of the Multifactorial Diseases will provide an excellent source to all professionals who would like to acquire information on the latest cutting-edge developments in genetics and pathogenetics of multifactorial diseases such a ... Read more

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University of Minnesota, Minneapolis. Epilepsy Research, Supplement #4. Based on a conference held at the Scanticon Conference Center in Plymouth, Minnesota, otherwise unidentified. Epilepsy research for geneticists and epileptologists. 30 Contributors, mostly U.S.. DNLM: Epilepsy - genetics - congresses. ... Read more

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This work provides details of the molecular biology of all the currently important coagulation and fibrinolytic factors as assessed using modern immunological probes and recombinant DNA techniques. The author emphasizes current genetic findings with regard to the molecular biology of hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency) and von Willebrand's disease. He also discusses in depth the molecular defects and biochemical abnormalities in patients with other hereditary coagulation and fibrinolytic disorders (especially atypical variants) and considers the assessment of carrier status and the characterization of molecular abnormalities in the fetus. Laboratory techniques using immunological principles and recombinant DNA methods are described in detail. ... Read more