81. Aplastic Anemia aplastic anemia and Lindane 5.3.9.7 Carcinogenicity TARGET ANALYTES.aplastic anemia Toxin Exposure. By Lyle L. Sensenbernner, MD In http://www.headlice.org/lindane/health/toxicology/aplastic_anemia.htm

Lindane Education And Research Network Select a Destination Homepage Animals Lindane Ban Cancer Chemistry Children Environment Health Effects Lindane Index Manufacturers Metabolism Products Product Recalls Superfund Toxicology Women HeadLice.Org Home Discussion Links Search ... Back Aplastic Anemia and Lindane Carcinogenicity Lindane has been classified as Group B2/C (probable/possible human carcinogen) (U.S. EPA, 1999c) and a cancer potency of 1.3 per mg/kg-d has been listed (HEAST, 1997). Lindane's related isomers, alpha and beta hexachlorocyclohexane, are classified as probable human carcinogens and have cancer potencies similar to that of lindane . In addition to tumors identified in experimental animals, human study data indicate that this chemical may cause aplastic anemia (U.S. EPA, 1993a). TOXICOLOGICAL PROFILE SUMMARIES FOR TARGET ANALYTES Aplastic Anemia Toxin Exposure By Lyle L. Sensenbernner, M.D. In many cases, aplastic anemia has been clearly linked to exposure to certain toxins, although in many cases it is unlikely that a specific case can be identified. Overall there are certain groups of substances which have been clearly shown to be causative agents for aplastic anemia. These include: Toxic chemicals;

82. Ask NOAH About: Anemia Anemia in Children About Anemia KidsHealth Anemia - KidsHealth aplastic anemia- Lucile Packard Children's Hospital Hemolytic Anemia - Lucile Packard http://www.noah-health.org/english/illness/blood/anemia.html

Ask NOAH About: Anemia What is Anemia? Care and Treatment Information Resources Basic Descriptions Anemia in Children ... Organizations What Is Anemia? Basic Descriptions About Anemia - KidsHealth All About Anemia - Anemia Life Line Anaemia Due to Red Cell Loss - BUPA Anemia - KidsHealth ... Anemia - Methodist Healthcare System, Houston TX (also in Spanish Anemia: When Low Iron is the Cause - American Academy of Family Physicians (also in Spanish Anemia, General - Mayo Clinic Anemia in Young Women - InteliHealth Anemias - ... Women's Health: Anemia - American Institute of Preventive Medicine Blood Basics Blood - TeensHealth Facts About Blood - Methodist Healthcare System, Houston TX Introduction to Hematology - Puget Sound Blood Center Red Blood Cells - Puget Sound Blood Center ... Anemia in Pregnancy Anemia in Children About Anemia - KidsHealth Anemia - KidsHealth Aplastic Anemia - Lucile Packard Children's Hospital Hemolytic Anemia - Lucile Packard Children's Hospital ... Thalassemia Anemia in Teens Iron and Teens: A Guide to Anemia Prevention - Children's Hospital, Boston MA

83. OUP USA: The Drug Etiology Of Agranulocytosis And Aplastic Anemia OUP Book The Drug Etiology of Agranulocytosisand aplastic anemia by Kaufman, David W. http://www.oup-usa.org/isbn/0195059832.html

Medicine or Browse by Subject In Stock Standard Monographs in Epidemiology and Biostatistics 18 ... Table of Contents The Drug Etiology of Agranulocytosis and Aplastic Anemia DAVID W. KAUFMAN, JUDITH P. KELLY, MICHA LEVY, and SAMUEL SHAPIRO, all of the Slone Epidemiology Unit, Boston University School of Medicine Agranulocytosis and aplastic anemia figure prominently among certain serious diseases which can be precipitated by drugs. Several hundred different agents with substantially different chemical and pharmacological properties have been implicated, although the evidence incriminating specific drugs has been largely anecdotal. This book describes the findings of a rigorous and comprehensive epidemiological investigation designed to provide reliable quantitative data on the drug etiology of agranulocytosis and aplastic anemia. This investigation was a large-scale, population based , case-control study. Its objectives were to identify those drugs associated with agranulocytosis and aplastic anemia, and to estimate incidence rates attributable to specific drugs. In both conceptual and practical terms, this study has broken new ground, by providing the most extensive documentation to date concerning the drug etiology and incidence of the two dyscrasias. 432 pp.; 2 illus.; 6-1/8 x 8-1/4; 0-19-505983-2

84. Aplastic Anemia -- ECureMe.com aplastic anemia, more about aplastic anemia, Hypoplastic anemia, refractoryanemia or panmyelo-phthisis. more about aplastic anemia, .. http://www.ecureme.com/emyhealth/data/Aplastic_Anemia.asp

April 3, 2003 Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health Ask The Doctor Lifestyle Counseling Ask by mail My Health Chart ... Hospitals Aplastic Anemia more about Aplastic Anemia Hypoplastic anemia, refractory anemia or pan-myelo-phthisis Of the many components that make up the cells e.g., red blood cells (carry oxygen), platelets (stop bleeding), white blood cells (fight infection) all are made in the bone marrow. The bone marrow is contained in the long and pelvic bones of the body. When the bone marrow is damaged or destroyed, the result is a lack of production of the cellular productions of blood resulting in aplastic anemia. Toxins, radiation, cancer chemotherapy, and medications are the main causes of this condition.

85. A To Z Encyclopedia Topic: Aplastic Anemia aplastic anemia. What is aplastic anemia? Aplastic What causes aplasticanemia? aplastic anemia in children has multiple causes. Some http://web1.tch.harvard.edu/cfapps/A2ZtopicDisplay.cfm?Topic=Aplastic Anemia

86. RP 98-15 - Hematologic Malignancy And Aplastic Anemia - Allogeneic Blood Or Marr Roswell Park Cancer Institute Allogeneic Blood or Marrow Transplantation forHematologic Malignancy and aplastic anemia. http://www.roswellpark.org/clinicaltrial.asp?lid=1740&reflid=389

87. SupportPath.com: Aplastic Anemia SupportPath.com, aplastic anemia. Other topics of interest on SupportPath.comAnemia, Cancer. None Listed. Clinical Trials Research on aplastic anemia http://www.supportpath.com/sl_a/aplastic_anemia.htm

Aplastic Anemia Other topics of interest on SupportPath.com: Anemia Cancer About Us Add-A-Link ... here Online Communities / Message Boards... Aplastic Central Website: http://aplasticcentral.com/default.htm Description: An extensive collection of online links to information on aplastic anemia and related conditions. Their forum is located here Date Added: 08/08/2002 Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... INTERNATIONAL Website: http://www.aplastic.org/ Description: Date Added: 08/08/2002 Note: Groups are listed alphabetically by U.S. state and then country. None Listed None Listed Professional Organizations of Interest... None Listed ClinicalTrials.gov: Aplastic Anemia Website: http://www.clinicaltrials.gov/ct/gui/action/SearchAction;jsessionid=D3D5A327087663B2F11222880552D7D4?term=aplastic+anemia Description: Search results for "Aplastic Anemia" from the National Institutes of Health (NIH).

88. Aplastic Anemia next up previous Next Thalassemia Up Atlas of Hematology Previous Case 45.aplastic anemia. Click the image to see a more detailed version. Case 1. http://pathy.med.nagoya-u.ac.jp/atlas/doc/node111.html

Next: Thalassemia Up: Atlas of Hematology Previous: Case 4¡¤5 Aplastic Anemia Click the image to see a more detailed version. Case 1 Bone Marrow biopsy, Hematoxylin and eosin stain, x100 Bone Marrow biopsy, Hematoxylin and eosin stain, x200 Bone Marrow biopsy, Hematoxylin and eosin stain, x200 Case 2 Bone Marrow biopsy, Hematoxylin and eosin stain, x100 Bone Marrow biopsy, Hematoxylin and eosin stain, x100 Bone Marrow biopsy, Hematoxylin and eosin stain, x100 [content] Nagoya University School of Medicine Department of Medicine The Branch Hospital Takuji Ichihashi, Tomoki Naoe Nagasaki University School of Medicine Department of Hematology Kazutaka Kuriyama Kyoto University College of Medical Technology Masataka Sasada Hamamatsu University School of Medicine Department of Medicine Three Ryuzo Ohno

89. Clinical Study: 00-H-0032, Treatment Of Severe Aplastic Anemia With Combined Imm Title Treatment of Severe aplastic anemia with Combined Immunosuppression AntithymocyteGlobulin (ATG) and Cyclosporine A (CSA), and Mycophenolate Mofetil http://clinicalstudies.info.nih.gov/detail/A_2000-H-0032.html

Protocol Number: 00-H-0032 Title: Treatment of Severe Aplastic Anemia with Combined Immunosuppression: Antithymocyte Globulin (ATG) and Cyclosporine A (CSA), and Mycophenolate Mofetil (MMF) Number: 00-H-0032 Summary: This study will test the safety and effectiveness of a combination of three drugs in treating severe aplastic anemia and preventing its recurrence. Two drugs used in this trial-ATG and cyclosporine-are standard combination therapy for aplastic anemia. This study will try to improve this therapy in three ways: 1) by altering the drug regimen to allow the drugs to work better; 2) by reducing the risk of kidney damage; and 3) by adding a third drug-mycophenolate mofetil-to try to prevent disease relapse. Patients with severe aplastic anemia who do not have a suitable bone marrow donor or who decline bone marrow transplantation may participate in this study. Patients will have a skin test for ATG allergy, chest X-ray, blood test, and bone marrow aspiration before treatment begins. ATG will then be started, infused through a vein continuously for 4 days. Ten days after ATG is stopped, cyclosporine treatment will begin, taken twice a day by mouth in either liquid or capsule form and will continue for 6 months. Also, in the first 2 weeks of treatment, patients will be given a full dose of corticosteroid (prednisone) to prevent serum sickness that could develop as a side effect of ATG therapy. The dosage will be decreased after that. Mycophenolate will be started at the same time as ATG, in two daily doses by mouth, and will continue for 18 months.

90. Aplastic Anemia .......aplastic anemia. Definition aplastic anemia is a disorder in which the bone marrowgreatly decreases or stops production of blood cells. http://www.chclibrary.org/micromed/00038280.html

Main Search Index Definition Description Causes ... Resources Aplastic anemia Definition Aplastic anemia is a disorder in which the bone marrow greatly decreases or stops production of blood cells. Description The bone marrow (soft tissue which is located within the hard outer shell of the bones) is responsible for the production of all the types of blood cells. The mature forms of these cells include red blood cells, which carry oxygen throughout the body; white blood cells, which fight infection; and platelets, which are involved in clotting. In aplastic anemia, the basic structure of the marrow becomes abnormal, and those cells responsible for generating blood cells (hematopoietic cells) are greatly decreased in number or absent. These hematopoietic cells are replaced by large quantities of fat. Yearly, aplastic anemia strikes about 5-10 people in every one million. Although aplastic anemia strikes both males and females of all ages, there are two age groups that have an increased risk. Both young adults (between 15-30 years of age) and the elderly (over the age of 60) have higher rates of aplastic anemia than the general population. While the disorder occurs worldwide, young adults in Asia have a higher disease rate than do populations in North America and Europe. Aplastic anemia falls into three basic categories, based on the origin of its cause: idiopathic, acquired, and hereditary.

91. Net-happenings: 00-04-06: RESOUR> [netsites] Aplastic Anemia And MDS RESOUR netsites aplastic anemia and MDS. aplastic anemia MDS (MyelodysplasticSyndromes) International Foundation, Inc. http//www.aamds.org/. http://scout.wisc.edu/addserv/NH/00-04/00-04-06/0011.html

Gleason Sackmann ( gleason@rrnet.com Thu, 6 Apr 2000 07:41:49 -0500 Messages sorted by: [ date ] [ thread ] [ subject ] [ author ] Next message: Previous message: From: Alan S. Harrell [ mailto:ASHandRR@MASTNET.net Sent: Thursday, April 06, 2000 6:37 AM To: netsites@egroups.com Subject: [netsites] Aplastic Anemia and MDS Inc. http://www.aamds.org/ Foundation, Inc. serves as a resource directory for patient assistance and emotional support; provides educational materials and updated medical information; financially supports research to find effective treatment for aplastic anemia and myelodysplastic syndromes." Alan ASHandRR@MASTNET.net Next message: Previous message:

92. Dorlands Medical Dictionary aplastic anemia, any of a diverse group of anemias characterized by bone marrowfailure with reduction of hematopoietic cells and their replacement by fat http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

93. Functional Features Of Hematopoiesis In Patients With Aplastic Anemia During Hig Functional Features of Hematopoiesis in Patients with aplastic anemia During HighAltitudeClimate Therapy. Key Words · aplastic anemia · climate therapy. http://pearl.sums.ac.ir/AIM/9923/raimjanov9923.html

Functional Features of Hematopoiesis in Patients with Aplastic Anemia During High-Altitude Climate Therapy A.R. Raimjanov MD, S.M. Mamatov MD Kyrgyz Scientific Center of Hematology, Bishkek, Kyrgyzstan Abstract Background No effective treatment for aplastic anemia, short of repeated blood transfusion and immunotherapy are currently available. Objective To investigate whether a stay at high altitude the so-called "climate-therapy" might stimulate hematopoiesis. Methods 202 patients aged 15-50 years were monitored hematologically at a high-altitude station on the northern portal of Tuya-Ashu Pass in Kyrkyzstan. The patients performed graduated physical exercise for 40 days. Results After adaptation at high altitude, reticulocytosis, gradual rise of granulocyte and platelet count were noted. Bone marrow examination also showed significant increase in erythroid, myeloid and megakaryocytic series with improvement in fibroblast colony forming efficacy. Conclusion High altitude may be recommended as an adjunct therapeutic for stimulating erythro-, leuko-, and thrombopoiesis and repeated courses may lead to a decrease in complications and prolonged remission.

94. BMTs For Aplastic Anemia From BMT Newsletter May 1995 Issue 29 BMTs for aplastic anemia Reprintedby NYSERNet with Permission from BMT Newsletter. BMTs for aplastic anemia. http://www.bmtnews.org/newsletters/may1995/aplastic.html

From BMT Newsletter May 1995 Issue # 29 - BMTs for Aplastic Anemia Reprinted by NYSERNet with Permission from BMT Newsletter BMTs for Aplastic Anemia Aplastic anemia is a disease of the bone marrow - the organ that produces the bodyUs blood cells. Approximately 2,500 people in the U.S. are diagnosed each year with aplastic anemia. Although the symptoms of aplastic anemia - fatigue, bruising, infections, and weaknessQare similar to those associated with leukemia, aplastic anemia is not a form of cancer. In patients with aplastic anemia the bone marrow stops producing, or produces too few, red blood cells, white blood cells and platelets. Without sufficient red blood cells, oxygen cannot reach organs and tissues throughout the body. A decrease in the number of white blood cells hampers the bodyUs ability to fight infection. Platelets are needed to help blood clot. Although the exact cause of aplastic anemia is unclear, most evidence points to a combination of factors: damaged "stem cells" (the primitive cells in bone marrow that produce blood cells), damage to the bone marrow environment in which blood cells develop, abnormalities in the proteins that regulate blood cell production, and a malfunctioning immune system that interferes with the normal blood cell production. Certain environmental factors have been associated with the development of aplastic anemia. Chemotherapy drugs such as busulfan or antibiotics such as chloramphenicolQas well as some drugs used to treat inflammations, epilepsy, or malariaQcan cause temporary or prolonged aplastic anemia. Chemicals such as benzene and pesticides, infections such as viral hepatitis and mononucleosis, autoimmune disorders and ionizing radiation also have been linked to development of aplastic anemia. Although exposure to these agents increases the risk of developing aplastic anemia, they are not the sole cause of the disease.

95. Health Ency.: Disease: Idiopathic Aplastic Anemia Idiopathic aplastic anemia See images. Idiopathic aplastic anemia is a failure ofthe bone marrow to properly form all types of blood cells. Causes and Risks. http://www.accessatlanta.com/shared/health/adam/ency/article/000554.html

SEARCH: The Web Yellow Pages HOME AJC.COM Illustrated Health Encyclopedia Important notice Ency. home Disease I Idiopathic aplastic anemia See images Overview Symptoms Treatment ... Prevention Alternative names: Anemia - idiopathic aplastic Definition: Idiopathic aplastic anemia is a failure of the bone marrow to properly form all types of blood cells. Causes and Risks Idiopathic aplastic anemia is a condition that results from injury to the stem cell, a cell that gives rise to other cell types after it divides. Consequently, there is a reduction in all cell types red blood cells, white blood cells and platelets with this type of anemia , which is called pancytopenia. The cause of idiopathic aplastic anemia is unknown, but is thought to be an autoimmune process (the body reacting against its own cells). Causes of other types of aplastic anemia may be chemotherapy radiation therapy toxins , drugs, pregnancy , congenital disorder, or systemic lupus erythematosus Symptoms arise as the consequence of bone marrow failure. Anemia (low red blood cell count ) leads to fatigue and weakness . Low white blood cell count, or leukopenia, causes an increased risk of infection. Low platelet count, or

96. Health Ency.: Disease: Secondary Aplastic Anemia Ency. home Disease S Secondary aplastic anemia. Secondary aplastic anemiaSee images. Anemia secondary aplastic; Acquired aplastic anemia. Definition http://www.accessatlanta.com/shared/health/adam/ency/article/000529.html

SEARCH: The Web Yellow Pages HOME AJC.COM Illustrated Health Encyclopedia Important notice Ency. home Disease S Secondary aplastic anemia See images Overview Symptoms Treatment ... Prevention Alternative names: Anemia - secondary aplastic; Acquired aplastic anemia Definition: Secondary aplastic anemia is a failure of the blood-cell forming capacity of the bone marrow that affects all blood-cell types. Causes and Risks Secondary aplastic anemia is a condition that is a result of injury to the stem cell, a cell that gives rise to other blood cell types when it divides and differentiates. Consequently, there is a reduction in all types of blood cells: red blood cells, white blood cells, and platelets (which is called pancytopenia). Causes of secondary aplastic anemia include chemotherapy , drug therapy to suppress the immune system, radiation therapy toxins such as benzene or arsenic, drugs, pregnancy , and congenital disorders. When the cause is unknown, it is then referred to as idiopathic aplastic anemia Symptoms arise as a consequence of bone-marrow failure. Anemia (a low red blood cell count ) leads to fatigue and weakness . A low white blood cell count (leukopenia) causes an increased risk of infection. A low

97. Aplastic Anemia aplastic anemia. aplastic anemia is a rare but very serious conditionin which the patient's bone marrow stops producing red blood cells. http://www.drhull.com/EncyMaster/A/aplastic_anemia.html

Help for sleepless parents Encyclopedia Index A aplastic anemia Search aplastic anemia red blood cells bone marrow transplantation. In pancytopenia, a related condition of bone marrow stem-cell failure, all cell lines are affected, including red and white cells as well as platelets.

98. Pathology - Table Of Contents Etiology, incidence, diagnosis and treatment of aplastic anemia. http://medic.uth.tmc.edu/edprog/00000146.htm

Pathology Fall 2002 Table of Contents Announcements Links to Online Lecture Videos Links to Immunopatholgy of Hypersensitivity Diseases Lecture Links to Immunodeficiency Lecture Pulmonary Powerpoint Presentations ... Pathology Image Booklets Block III General Course Policies and Information General Course Information Videotaping Policy UTMS Guidelines of Academic Dishonesty Contact Information and Faculty Participants ... Block 3 Lecture Schedule Laboratory Images Block 3 Lab Images Infectious Disease Lab Infectious Disease Lab Infectious Disease Lab Answers Endocrine Disease Lab Endocrine Disease Lab Endocrine Disease Lab Answers Male Reproductive Disease Male Reproductive Lab Male Reproductive Lab Answers Pediatric Disease Lab Pediatric Pathology Lab, Part 1 Pediatric Pathology Lab, Part 2 Female Reproductive Disease Lab Female Reproductive Lab I Female Reproductive Lab II Gastrointestinal Disease Lab Gastrointestinal Lab I, Part 1

99. Aplastic Anaemia & Myelodysplasia Index Page aplastic Anaemia Myelodysplasia Glossary, There are absolutelyno commissions and no expenses paid to our fundraisers. You can http://www.btinternet.com/~randy.ramage/aamdsglossary_folder/

Please Support the Aplastic Anaemia Trust Aplastic Anaemia Myelodysplasia Glossary There are absolutely no commissions and no expenses paid to our fundraisers. You can send your cheque to: Tamsin Fraser Aplastic Anaemia Trust St. George's Hospital Medical School Cranmer Terrace London, SW17 ORE Introduction The following is a list of the words I have come across and looked up in my study of Aplastic Anaemia and Myelodysplasia since I was diagnosed with AA July 20th 2001. This list may not be complete so I may update this glossary as I come across new words which are vital to understanding the conditions and making decisions on the treatments, diet and change in lifestyle. There is a reason the technical jargon of the Medical profession looks Greek to you. It is! With respect to Hypocrites who was a Greek born 460 BC and who was the father of modern medicine, most medical terms are made out of Greek words strung together. Understanding where the word came from, it's derivation, helps to understand the word and to further understand all the words like it. I have included the derivations of all of the words I could for this reason. I hope you find this glossary helps to clarify what the Doctors and articles are talking about.

100. Www.theaat.org.uk/ http://www.theaat.org.uk/

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