41. Arthritis Research Campaign | Antiphospholipid Syndrome antiphospholipid syndrome (APS) is a disorder in which the bloodhas a tendency to clot too quickly ('sticky blood' syndrome). http://www.arc.org.uk/about_arth/booklets/6059/6059.htm

scotland + n. ireland north wales + midlands east + southeast ... south + southwest What is antiphospholipid syndrome (APS)? Antiphospholipid syndrome (APS) is a disorder in which the blood has a tendency to clot too quickly ('sticky blood' syndrome). The clotting can affect any vein or artery in the body, resulting in a wide range of symptoms. These are described below. (The medical words in italics are explained in more detail in the Glossary at the end of the booklet.) History of APS Most of the early work leading to the detailed description of APS was carried out in the early 1980s by Dr Graham Hughes and his colleagues while studying a disease called lupus (see ARC booklet ' Lupus '). In lupus the immune system goes into 'overdrive' and produces a huge variety of excess antibodies . While studying lupus it became clear that some patients had a tendency to form blood clots in arteries and veins. This clotting was associated with a particular antibody which 'attacks' phospholipids - hence the term antiphospholipid antibodies . It was discovered that the syndrome could exist in people without lupus. This is now known as APS or primary antiphospholipid syndrome. What are the main signs and symptoms?

42. SupportPath.com: Antiphospholipid Syndrome SupportPath.com, antiphospholipid syndrome. Also called Hughes Syndrome. NoneListed. Clinical Trials Research on antiphospholipid syndrome http://www.supportpath.com/sl_a/antiphospholipid_syndrome.htm

Antiphospholipid Syndrome Also called: Hughes Syndrome About Us Add-A-Link Email Gallery ... here Online Communities / Message Boards... None Listed Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... UNITED KINGDOM Hughes Syndrome Foundation Website: http://www.hughes-syndrome.org/ Description: The aims of this registered charity: To offer understanding and support to sufferers of Hughes Syndrome; To offer information and education on Hughes Syndrome; To support research into the condition; To raise funds to provide information, education and research. Website includes information about Hughes Syndrome (Antiphospholipid Syndrome), research, and information on support groups. Date Added: 08/08/2002 Note: Groups are listed alphabetically by U.S. state and then country.

43. JH Autoimmune Skin Disorders Center - Connective Tissue Diseases CONNECTIVE TISSUE DISEASES. antiphospholipid syndrome. Dermatomyositis. LupusErythematosus. Porphyrias. Connective Tissue Diseases. antiphospholipid syndrome http://www.hopkinsmedicine.org/dermatology/AISDC/ctdisease/

DEPARTMENT OF DERMATOLOGY AUTOIMMUNE SKIN DISEASES CENTER VISUAL KNOWLEDGE BASE BLISTERING SKIN DISEASES CONNECTIVE TISSUE DISEASES Antiphospholipid Syndrome Dermatomyositis ... CUTANEOUS VASCULITIDES CONTACT INFORMATION All correspondance should be addressed to the following (attn: Dr. Hossein C. Nousari) or via email. Division of Dermatoimmunology Johns Hopkins Medical Institutions Room 771 Ross Research Building 720 Rutland Avenue Baltimore, MD 21205 (410) 955-2992 (phone) (410) 955-0520 (fax) hnousar@jhmi.edu Connective Tissue Diseases Antiphospholipid Syndrome This diseases can be seen in patients with lupus and other autoimmune diseases (secondary) and also in patients without any underlying autoimmune disease (primary). These patients commonly present to dermatologists with skin ulcers, digital infarcts, and livedo reticularis ( purplish mottling of the skin. However, more serious internal complications can be seen including recurrent abortions, deep venous thrombosis, and thrombosis of internal arterial and venous blood vessels. The diagnosis is made by detecting the presence of anti cardiolipin antibodies and also the presence of lupus anticoagulant tests (coagulation studies). These patients require anticoagulation therapy and wound care. Dermatomyositis Click on these images for full sized versions.

44. Antiphospholipid Syndrome Then in 1983 Hughes provided the first detailed description of theantiphospholipid syndrome (described in Amengual et al, 1998). http://www.nurseminerva.co.uk/antiphospholipid_syndrome.htm

Home anaesthesia asthma biorhythms ... pathology question received: Can you tell me what is the antifosfolipidic syndrome, my wife has it? She has thrombocitopenia too. Her platelets are 100. response: Can you tell me what is the antifosfolipidic syndrome, my wife has it? She has thrombocitopenia too. Her platelets are 100. th February 2001 During the late 1970s it was recognized that blood clotting disorders can be linked with the appearance of certain antibodies in the blood. Then in 1983 Hughes provided the first detailed description of the antiphospholipid syndrome (described in Amengual et al , 1998). The main clinical features of this syndrome are the repeated formation of inappropriate blood clots (thromboses) in arteries and veins, miscarriages during pregnancy, and commonly a reduction in the number of platelets in the blood. Platelets are also known as thrombocytes because of their contribution to the process of blood clotting, and if they are present in reduced numbers the condition is called thrombocytopenia. Thrombocytopenia occurs in approximately 20 to 40% of the patients with antiphospholipid syndrome (Galli, Finazzi, and Barbui, 1996). Antiphospholipid syndrome may occur on its own or it may be associated with other autoimmune diseases such as systemic lupus erythematosus (Gromnica-Ihle and Schossler, 2000). The blood clots that occur in antiphospholipid syndrome can affect vessels of all sizes (Khamashta and Hughes, 1995).

45. Member Sign In The combination of heparin plus aspirin has been recommended as primarytherapy for antiphospholipid syndrome in pregnancy. Focus On http://www.medscape.com/viewarticle/447113

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46. Member Sign In Impact of the antiphospholipid syndrome A Critical Coagulation Disorderin Women from Medscape Women's Health eJournal TM Thomas http://www.medscape.com/viewarticle/408839

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47. PRIMARY ANTIPHOSPHOLIPID SYNDROME; DIFFERENTIATION FROM MULTIPLE SCLEROSIS Return to contents page. PRIMARY antiphospholipid syndrome; DIFFERENTIATIONFROM MULTIPLE SCLEROSIS A Study of 22 Cases. AR Nikseresht*, Gh. http://www.sums.ac.ir/IJMS/0012/nikseresht0012.html

Return to contents page PRIMARY ANTIPHOSPHOLIPID SYNDROME; DIFFERENTIATION FROM MULTIPLE SCLEROSIS A Study of 22 Cases A.R. Nikseresht*, Gh. R. Rezaeian**, M. Hakim*** Department of Internal Medicine, Divisions of * Neurology, ** Cardiology and ***Rheumatology, Shiraz University of Medical Sciences, Shiraz, Iran ABSTRACT Background/Objective: Anti-phospholipid syndrome (APS) is a well-known cause of thrombosis and can mimic multiple sclerosis (MS). We analyzed the neurologic manifestation, laboratory and MRI findings of our patients with primary APS (PAPS) in an attempt to identify parameters that might differentiate the two entities. Methods: Of 180 cases with the diagnosis of probable or definite MS, we studied 29 patients who had symptoms suggesting an underlying systemic disease, unusual laboratory findings or atypical evolution for MS. Of these, 22 patients (15 female and 7 male, mean age 30 year) proved to have PAPS with antiphospholipid antibody (aPL) positivity (titer 10 GPL units) and were followed-up for at least 8 months. Brain MRI was performed in all of the patients.

48. Antiphospholipid Antibody Syndrome Antiphospholipid Antibody Syndrome antiphospholipid syndrome. Book,Home Page. http://www.fpnotebook.com/RHE16.htm

Home About Links Index ... Editor's Choice Paid Advertisement (click above). Please see the privacy statement Rheumatology Diffuse Assorted Pages Amyloidosis Antiphospholipid Antibody Syndrome Systemic Lupus Erythematosus Polymyalgia Rheumatica ... Medication Causes of Myositis Antiphospholipid Antibody Syndrome Antiphospholipid Syndrome Book Home Page Cardiovascular Medicine Dental Dermatology Emergency Medicine Endocrinology Gastroenterology General Medicine Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Rheumatology Index Bone Cardiovascular Medicine Diffuse Examination Infectious Disease Intra-Articular Disorders Laboratory General Marfans Myofascial Neurology Osteoarthritis Pain Pediatrics Pharmacology Procedure Radiology RA Spondylitis Symptom Evaluation Page Diffuse Index Amyloidosis Behcets Syndrome Lupus Anticoagulant Lupus Systemic Polymyalgia Rheumatica Polymyositis Background Polymyositis DDx Polymyositis Evaluation Polymyositis Management Polymyositis Types Idiopathic Scleroderma Sjogren's Pathophysiology Recurrent thrombosis of any size vessel May have no link with SLE despite early associations Diagnosis Major clinical associations Venous thrombosis Deep Vein Thrombosis Pulmonary Embolism Arterial thrombosis Cerebrovascular Accident (CVA) Transient Ischemic Attack s Myocardial Infarction Gangrene

49. CCHS Clinical Digital Library antiphospholipid syndrome Clinical Resources. antiphospholipid syndrome Accessdocument; Antiphospholipid Antibody Syndrome and Pregnancy Access document; http://cchs-dl.slis.ua.edu/clinical/immunology/autoimmune/antiphospholipid-syndr

Clinical Resources by Topic: Immunology Antiphospholipid Syndrome Clinical Resources Emergency Pediatrics Geriatrics Pathology ... Miscellaneous Resources See also: General Immunology Clinical Resources Antiphospholipid Syndrome Patient/Family Resources Harrison's Principles of Internal Medicine 15th Ed.-2001: Table of contents Health Sciences Library subscription INFO Chapter 307: Autoimmunity and Autoimmune Diseases: Table of contents Introduction: Access document Mechanisms of Autoimmunity Access document Genetics: Access document Immunopathogenic Mechanisms in Autoimmune Diseases: Access document Autoimmune Disease: Access document Introduction: Access document Organ-Specific versus Systemic Autoimmune Diseases: Access document Systemic Autoimmune Disease Access document Chapter 275: Glomerulopathies Associated with Multisystem Diseases: Table of contents Introduction: Access document Immunologically Mediated Multisystem Diseases: Access document Introduction: Access document Antiphospholipid Antibody Syndrome and Thrombotic Microangiopathy: Access document Ruddy: Kelly's Textbook of Rheumatology 6th Ed.-2001 (MD Consult):

50. WSOCTV.com - Health - Antiphospholipid Syndrome antiphospholipid syndrome. antiphospholipid syndrome (APS) is a conditionin which the blood is prone to clotting. Phospholipids http://www.wsoctv.com/health/1979066/detail.html

Search Make WSOCTV.com Your Homepage Contact the Station Sign up for E-News WSOC-TV Experts ... Health Email This Story Print This Story Antiphospholipid Syndrome Antiphospholipid Syndrome (APS) is a condition in which the blood is prone to clotting. Phospholipids are fatty molecules that make up part of a cell membrane. In patients with APS, the body mistakenly recognizes certain phospholipids as foreign invaders and produces antibodies to attack them. The process can cause inflammation and clotting of the blood. Blood clots can develop in any part of the body. A common site of clotting is the brain, which can lead to a stroke. Researchers estimate as many as one-third of strokes in young patients (under 50) are caused by APS. Clotting in the heart can cause a heart attack. About one-third of patients also have heart valve abnormalities. Other common sites of clots include the leg veins (leading to the development of leg ulcers) and kidneys. APS and Pregnancy Complications Women with APS may have difficulties with pregnancy. During pregnancy, women are at higher risk of developing blood clots and preeclampsia. Some women may have trouble getting pregnant, while others may experience repeated miscarriages. Blood clots that develop in the placenta can cause fetal growth problems, fetal distress, preterm birth, or pregnancy loss. There is no cure for APS, but there is treatment. During pregnancy, physicians may recommend low doses of aspirin and daily injections of the blood thinning drug, heparin. The therapy is started at the beginning of pregnancy and halted just before delivery to reduce the risk of bleeding during childbirth. Soon after birth, the treatment resumes for about six weeks because of an increased risk for clotting in the postpartum period.

51. Antiphospholipid Syndrome Articles, Support Groups, And Resources antiphospholipid syndrome articles, support groups, and resources for patientsfrom Med Help International (www.medhelp.org). antiphospholipid syndrome. http://www.medhelp.org/HealthTopics/Antiphospholipid_Syndrome.html

[Health Topics A-Z] A B C D ... Z Antiphospholipid Syndrome Medical Glossary: ANTIPHOSPHOLIPID SYNDROME Ask The Doctor Forums Antiphospholipid Syndrome and Chronic Headache (Neurology and Neurosurgery Forum) [Med Help Home] [Library Search] [Medical Forums] ... [Patient Network] Revised: 3/30/2003

52. ANTIPHOSPHOLIPID SYNDROME antiphospholipid syndrome An uncommon disorder that is characterized by hypercoagulabilitydue to the presence of antibodies against phospholipids These http://www.medhelp.org/glossary2/new/GLS_0436.HTM

ANTIPHOSPHOLIPID SYNDROME - An uncommon disorder that is characterized by hypercoagulability due to the presence of antibodies against phospholipids These patients exhibit a tendency for recurrent and life-threatening thrombosis and embolic events (e.g. stroke ). Individuals with antiphospholipid syndrome or APS, also have an increased tendency toward deep venous thrombosis myocardial infarction and spontaneous abortions in females. APS may be seen by itself or in association with other autoimmune illnesses (e.g. lupus ) or with some infections . Treatment includes long-term heparin and warfarin. Med Help Home Search Ask the Doctor Patient Network The medical glossary has been made possible by a generous donation from:

53. Flower's Antiphospholipid Syndrome Page antiphospholipid syndrome (APS), also known as Hughes syndrome for the doctor whofirst discovered it, is the name given to a disease which involves the immune http://canadianflower.tripod.com/aps.htm

This page is going to be a work in progress as I plan to add information as I find it or as it comes available.If you have any information you'd like to add, contact me . Let me know you were here, sign my guestbook Antiphospholipid syndrome (APS), also known as Hughes syndrome for the doctor who first discovered it, is the name given to a disease which involves the immune system. Normally antibodies are good and they help fight germs or viral infections from outside, however, occasionally the immune system makes the wrong kind - a type that acts against the body itself. It is a disorder in which the blood clotting system begins to form blood clots in the veins or arteries without obvious reason. The symptoms of Antiphospholipid Syndrome include blood clots (thromboses) in leg or arm veins and/or arteries; blood clots which travel to the lungs (pulmonary emboli); sudden loss of vision; occasional episodes of numbness, tingling, or weakness in the face or limbs; stroke; seizures; and recurrent miscarriages. All of these symptoms are the result of blood clots occurring in small to medium sized blood vessels. Most people affected with this disorder have only one or two of any of these symptoms. They are however at risk for developing additional symptoms if not treated appropriately or monitored by a physician knowledgeable about the disorder.

54. JAMA Women's Health Information Center - Antiphospholipid Obstet Gynecol Vol. 100, pp 408413, September 2002 antiphospholipid syndromein Pregnancy A Randomized, Controlled Trial of Treatment ABSTRACT. http://www.ama-assn.org/special/womh/library/scan/vol_8/no_28/farquharson.htm

55. ORPHANET® : Antiphospholipid Syndrome Translate this page ORPHANET. ORPHANET database access. antiphospholipid syndrome.Direct access to details Alias Lupus anticoagulant. Home Page. http://www.orpha.net/static/GB/antiphospholipid.html

ORPHANET database access Antiphospholipid syndrome Direct access to details Alias : Home Page

56. High-Risk Pregnancy - Antiphospholipid Syndrome (aPL) Site Search. Find A Doctor. antiphospholipid syndrome (aPL). What is antiphospholipidsyndrome (aPL)? antiphospholipid syndrome was only defined in recent years. http://www.chkd.org/High_Risk_Pregnancy/autoapl.asp

More Health Information Adolescent Medicine Allergy/Immunology Anesthesiology Arthritis Burns Cardiology Craniofacial Dental Medicine Dermatology Developmental Peds Diabetes Digestive Ear, Nose, Throat Genetics Gastroenterology Growth Hematology High Risk Newborn High Risk Pregnancy Infectious Disease Mental Health Neonatology Nephrology Neurology Normal Newborn Normal Pregnancy Oncology Ophthalmalogy Orthopaedics Otolaryngology Pediatric Intensive Care Pediatric Surgery Pediatrics Physical Medicine Plastic Surgery Respiratory/Pulmonology Rheumatology Safety Surgery Terminal Transplant Urology Site Search Antiphospholipid Syndrome (aPL) What is antiphospholipid syndrome (aPL)? Antiphospholipid syndrome is an autoimmune disease in which the body produces large amounts of antiphospholipid antibodies. Phospholipids are a special type of fat containing phosphate that makes up the outer walls of the body’s cells. Antiphospholipid antibodies attack the phospholipids. This causes many different problems including increased blood clotting. Cardiolipin is one type of phospholipid and specific anticardiolipin antibodies may develop. This disease is about two times more common in women than men. It is generally characterized by the following:

57. NMAP: The UK's Gateway To High Quality Internet Resources In Nursing, Midwifery, antiphospholipid syndrome up. antiphospholipid syndrome pregnancy,This is one of a series of pregnancyrelated information leaflets http://nmap.ac.uk/browse/mesh/detail/C0085278L0085587.html

Antiphospholipid Syndrome [up] Related topics: broader Autoimmune Diseases other Arthritis, Rheumatoid Dermatitis Herpetiformis Diabetes Mellitus, Insulin-Dependent Goodpasture Syndrome ... Thyroiditis, Autoimmune This is one of a series of pregnancy-related information leaflets produced by Dr. Danny Tucker, a UK-based Specialist Registrar in Obstetrics and Gynaecology. This document explains what Antiphospholipid syndrome is, the incidence of the syndrome, the problems it can cause, and possible prevention of these problems. Antiphospholipid Syndrome Patient Education Handout [Publication Type] Pregnancy Complications Last modified 28/Mar/2003 [Low Graphics]

58. NEJM -- Sign In Review Article from The New England Journal of Medicine The AntiphospholipidSyndrome. 84. Catastrophic antiphospholipid syndrome. http://content.nejm.org/cgi/content/short/346/10/752

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP The full text of the Journal is available online for all subscribers to the print version. For Original Articles and Special Articles, six months after publication the full text becomes available to all registered users. Registered Users User Name Password Remember my user name and password. Forgotten the password? If you do not use cookies sign in here If you have purchased access to an article or the Journal website, you may regain access here First-Time Users If you are a Journal subscriber using the Journal On-line for the first time, you must register and choose a password. If you are not a Journal subscriber subscribe here If you would like full access to the Journal Web site for 24 hours for $29, click here To regain access to Journal Web site, click here If you would like full access to this article for $10, click here To regain access to a purchased article, click here If you would like free full access to all Original Articles and Special Articles beginning six months after publication register here If you cannot get past this page

59. Physicians Reference Laboratory - Test Update: Antiphospholipid Syndrome Evaluat Testing Updates. 9192/APLEVL, antiphospholipid syndrome Evaluation, Effective3/11/2002. Beta2 Glycoprotein Antibodies added; CPT code changes. http://www.prlnet.com/UpdTest_20020311_APLEVL.htm

Testing Updates 9192/APLEVL Antiphospholipid Syndrome Evaluation Effective 3/11/2002 Beta-2 Glycoprotein Antibodies added; CPT code changes Beta-2 Glycoprotein I IgG: Beta-2 Glycoprotein I IgM: Beta-2 Glycoprotein I IgA: CPT Codes: 85613, 86146 x 3, 86147 x 3, 86148 x 3

60. High-Risk Pregnancy - Antiphospholipid Syndrome (aPL) antiphospholipid syndrome (aPL). What is antiphospholipid syndrome(aPL)? How does pregnancy affect antiphospholipid syndrome (aPL)? http://www.southeastmissourihospital.com/health/kids/hrpreg~1/autoapl.htm

Antiphospholipid Syndrome (aPL) What is antiphospholipid syndrome (aPL)? Antiphospholipid syndrome is an autoimmune disease in which the body produces large amounts of antiphospholipid antibodies. Phospholipids are a special type of fat containing phosphate that makes up the outer walls of the body’s cells. Antiphospholipid antibodies attack the phospholipids. This causes many different problems including increased blood clotting. Cardiolipin is one type of phospholipid and specific anticardiolipin antibodies may develop. This disease is about two times more common in women than men. It is generally characterized by the following: thrombosis - blood clots in arteries or veins (especially in the legs). Clots in vessels of the central nervous system (brain and spinal cord) can result in stroke. thrombocytopenia - low platelets (cells important in blood clotting). pregnancy loss (especially repeated losses) Antiphospholipid syndrome was only defined in recent years and is sometimes called Hughes syndrome, or sticky blood syndrome. The disease may occur along with other autoimmune diseases such as systemic lupus erythematosus (SLE, or lupus).

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