Extractions: Composition of Matter Patent Allowed on Unique CTLA4-Ig Product Form NEEDHAM, MA April 18, 2002 (Nasdaq: RGEN) announced today that it has received Medicines Control Agency (MCA) approval to conduct a clinical trial in the United Kingdom to assess the safety and efficacy of CTLA4-Ig in patients with refractory auto-immune thrombocytopenic purpura (ITP). A total of 12 patients with ITP will be treated in a Phase 1/2 open label, dose escalating clinical trial. In 2001, we completed a Phase 1 clinical trial of intravenously administered CTLA4-Ig in 12 normal adults who received escalating doses of CTLA4-Ig in which no serious adverse events or toxicities were observed. "We are pleased to initiate this trial which will serve to evaluate the in vivo activity of CTLA4-Ig in an auto-immune disease patient population," said Walter C. Herlihy, President and CEO of Repligen. "If successful, we believe that CTLA4-Ig may additionally be useful in treating other auto-immune diseases such as multiple sclerosis and rheumatoid arthritis." ITP is an auto-immune disease in which the body makes antibodies that target a patient's own blood platelets resulting in premature platelet destruction and an impaired ability to form blood clots. The clinical consequences of ITP are largely dependent on platelet count and range from bruising, mucosal bleeding and nosebleeds to intracranial hemorrhage, which can be fatal. There are approximately 25,000 people in the United States with refractory ITP. CTLA4-Ig is being evaluated in this patient population for its ability to interrupt the body's attack on the platelets. Clinical outcome will be monitored by change in platelet number following treatment.
Novel Drug Fights Autoimmune Disorders No one yet understands why these autoimmune disorders occur, but this drug may experiencehigh rates of kidney failure because of an autoimmune syndrome that http://www.umich.edu/~urecord/0203/Mar10_03/12.shtml
Extractions: A new drug candidate previously found to be effective in reducing harmful side effects of the autoimmune disease lupus also works to prevent arthritis-related complications without damaging normal immune system function. A healthy immune system recognizes friend from foe to protect the body against invading bacteria and viruses. But in lupus and arthritis, the cells of the immune system fail to self-destruct and get out of the way as normal cells should, and can turn against the body's own tissues, damaging joints and organs. No one yet understands why these autoimmune disorders occur, but this drug may offer a way to slow or prevent the damage caused by these misbehaving immune system cells, the authors say. "Our compound is more selective than current drugs," says lead author Gary Glick, a charter faculty member of the Life Sciences Institute, who is the Werner E. Bachmann Collegiate Professor of Chemistry and a professor of biological chemistry in the Medical School. "The lupus treatments in use now just wreck your bone marrow." Current treatments suppress normal immune system function in general, leaving patients more vulnerable to infection. But Bz-423 acts selectively, triggering the self-destruct mechanism in just the immune system cells that are malfunctioning. The bone marrow, where new immune system cells are manufactured, is unharmed by the drug.
Jules : What's Wrong? and far too much waiting, she was diagnosed as having autoimmune Hepatitis when weeventually contacted the National Organization for Rare disorders, we found http://scribble.com/jules/wrong.html
Extractions: One day in 1995, my sister, Jules, felt a bit sick pain in her abdomen and was a bit jaundice (yellow-tinted). After a lot of tests, and far too much waiting, she was diagnosed as having Auto-Immune Hepatitis What is this, you say? Well, so did we. The doctors told us little information, for little information is known about it. It is a rare disease, one that has not been studied much. In fact, when we eventually contacted the National Organization for Rare Disorders , we found out that they had no prepared document on it, and could only point us to some medical journal articles. It is important to know that it is not related to what are commonly called "hepatitis" Hepatitis A, B, C. These are afflictions which affect the liver directly, whereas auto-immune hepititis is a problem with the immune system, which in turn affects the liver. Auto-immune hepititis is so recently recognized that it is still called by different names. Apparently it is often mis-diagnosed. Curiously, about 70% of the cases seem to be in young females. My sister was 23 when she was diagnosed with it. No one seems to know the cause of the disease, but
Pets 4 Life - Article 1 like the skin, pancreas or thyroid is called an auto-immune disease. . My impressionis that the incidence of allergies and immune disorders has greatly http://www.pets4life.com/art1.html
Extractions: Causes and Treatment of pet allergies. Allergies occur when a pet reacts to food, pollution, chemical, dust, plant pollen, or/and something that is usually harmless to the body. The body tries to protect itself from the allergen. Thus, depending on where the allergy is occuring that organ reacts to the foreign substance. It could be a skin allergy and thus we see rashes or we see diarrhea caused by a food allergy. The reaction we see is the bodies way of expelling the foreign material. Many different types of reactions can occur as a result of the body fighting the foreign substance. This is why it is called an auto-immune disease. Therefore, to treat the pet allergy more information would need to be gathered from the pet and pet's owner. Your veterinarian would need to know a full history. The following are some examples of allergies and how they would be treated. I have also included some more information from my resources regarding cause and treatment of pet allergies. From British Institute of Homeopathy: Allergic Asthma - Belladonna, Aspergillis, Aconite, Pulsate, Silcea
Genentech: Research - Focus Areas the same immune cells that once defended the body against foreign pathogens cancause a number of autoimmune and inflammatory disorders capable of affecting http://www.gene.com/gene/research/focusareas/
Extractions: Genentech's research organization focuses its efforts on basic and applied science in Oncology Immunological Disease , and Vascular Biology . Genentech channels much of its substantial scientific resources and expertise in these three directions because there is a clear and compelling need for the development of safer and more efficacious therapies in these disease areas. In addition, the company also remains open to discoveries that may lead to therapies for unmet needs outside of oncology, immunological disease and vascular biology. Oncology Many departments in Research focus on oncology, including Molecular Oncology, Molecular Biology, Protein Engineering, Protein Chemistry, Physiology, Pathology, Bioorganic Chemistry and Bioinformatics. The Molecular Oncology Department's mission, in particular, is to identify novel mediators of critical cellular functions that play a role in cancer. To accomplish this goal, the department integrates research efforts in the following areas of molecular tumor biology: cellular self-renewal, differentiation, and fate-determination; cell cycle control; programmed cell death; and metastatic cell growth. The department aims to develop in vitro systems and in vivo models to elucidate the physiology of these novel mediators and illuminate the possibilities for related therapeutics.
Feedback/reports Of H-S IMMUNE disorders (CFIDS, Fibromyalgia, EBV, ChronicViral Infections). level of healthand well-being for those who have a variety of auto-immune based illnesses http://www.hemi-sync.com/feedback/immune.html
Extractions: Epstein-Barr and Chronic Fatigue Immune Dysfunction has left me severely debilitated, very weak, and often in pain. I am finding the Pain Control tape very effective, and I feel a tremendous amount of energy surge through my body when I listen to Energy Walk Pain Control Restorative Sleep, and Immunizing to my collection, and experienced wonderful results. Within several months of using them, the aching in my body subsided and my overall energy increased quite substantially. Hemi-Sync tapes continue to give me relief. My sister and I both have CFIDS, and a big part of the syndrome is the inability to get quality sleep. Usually I couldn't sleep without the aid of sleeping pills. Since I began using the Hemi-Sync tape Deep 10 Relaxation , I have been able to nap in the afternoon and have found a good night's sleep for the first time in many years. With the Positive Immunity Program , my sister and I have learned some very good techniques for managing other symptoms.
Extractions: Brain damage due to ageing alone (as opposed to pathological ageing) is minimal. Although the ageing brain may lose 100,000 neurons a year, the brain seems to compensate for these losses. This compensation could be positively influenced by intellectual challenge (by mental exercises). In fact, appropriate brain stimulation may cause brain cells (neurons), to branch wildly. This branching causes millions of additional connections (synapses), between brain cells and compensates cell loss.
Extractions: Reporting Adverse Reactions to Vaccines Vaccines, Infectious Diseases and the Canine Immune System: The Importance of Weighing the Risk to Benefit Ratio Vaccines, both in human and animal medicine, have come under attack recently with critics blaming adverse reactions and long-term health disorders on their wide-spread and frequent use. However, most immunologists agree that the risks of disease far outweigh the risks associated with the process of vaccinating. Unfortunately, to those humans and pets who comprise the minority high-risk group for vaccine reactions, the advantages offered by vaccines are understandably overshadowed by fears of debilitating or even fatal adverse reactions. The following article provides a brief overview of the canine immune system and the benefits which canine vaccines provide. Additionally, the controversy of vaccination is examined in relation to underlying health disorders or situations that may increase potential risk to adverse reactions. List of Contents The Canine Immune System How the Immune System Works Vaccines:Preparing the Immune System in Advance for Invasion The Theory Behind Vaccination ... Risks and Consequences of Canine Infectious Diseases Canine Distemper Canine Adenovirus Type-1 and Type-2 Canine Bordetella Canine Leptospirosis
They Shoot Horses But Vaccinate Dogs investigations being carried out by the Royal Veterinary College, it has been observedthat many of these autoimmune diseases commence as skin disorders. http://www.positivehealth.com/permit/Articles/Animals/horses.htm
Extractions: Subscribe Message Board ... Links Air your views on our message board Return to our home page Over 1000 searchable articles on all areas of complementary medicine Current and back issues of Positive Health Magazine Extensive research on the use of complementary medicine for a wide variety of conditions Would you like to become a practitioner? Click here to find the right course! Links to websites that sell a carefully selected range of natural health products Need a massage? Looking for a homeopath? Click here to find a therapist near you! Links to other websites we have found useful Buy single issues of Positive Health or subscribe to enjoy great discounts! Get the latest news for health, business, sport, entertainment, IT and current affairs Have a look at our great selection of webcams from around the world! Other articles on Animals They Shoot Horses but Vaccinate Dogs by Chrissie Mason B.R.C.P., Ph.D. Have you ever wondered why some dogs or cats continually experience skin problems? Have you ever wondered why your dog has to constantly have its anal glands evacuated? Have you ever wondered why your friend's dog experiences allergies to grass pollens, fleas, house dust mites etc? Have you ever thought your own diligence in conforming to a Veterinary Surgeon's request, and the annual vaccine programme could, in fact, be killing your beloved pets, rather than improving their quality of life? Perhaps you are inadvertently exposing them to the ravages of the 20th century illnesses, of immune deficiency diseases.
Autoimmunity AARDA American Autoimmune Related Diseases Includes extensive patient information about autoimmunity and autoimmune related diseases.Category Health Conditions and Diseases Immune disorders auto-immuneNational Office 22100 Gratiot Ave. E. Detroit, MI 48021 (586)7763900Washington Office 750 17th Street, NW Suite 1100 Washington http://www.aarda.org/
Extractions: Research Plan funded in this congressional year Links to other sites can be accessed through this home page. Such external Internet addresses contain information created, maintained or otherwise posted by organizations independent of the AARDA. The Association does not endorse, approve, or certify any information at such addresses. Reference to any product or service does not constitute any endorsement of such product or service by the Association.
References To Immune Posts On The Emotions emotions * 240 17-Mar anna3md@aol.com Re stress, AI disorders, childhood abuse igg@intrepid.netProzac * 576 24-Jun Lloyd@amug.org Hypothyroidism auto-immune? http://www.immuneweb.org/emotionrefs.html
Extractions: Immune posts relating to mind-body, emotions, psychology, stress, and child abuse. Posts that discuss child abuse issues directly are marked with an astrix (*). Posts that mention Multiple Personalities are marked with a percent (%). Note that some posts are missing because not all subject headers are complied. Missing files are: Oct-Dec 1994 and Jul-Dec 1995. There is a large discussion on child abuse in late spring or early summer 1995 that is not listed here. Please point out any posts within included months that I have missed. Your best bets to get most of the discussion is to download the archive files: , href="ftp://ftp.best.com/pub/cnorman/public_html/archives/jul95">jul95 somatic Cyndi Norman / immune@best.com / Last Modified: 1/31/97 Return to Immune-Related Resources
Auto-immune Diseases 2 autoimmune diseases 2. extraocular muscles. It may occur alone orin combination with other autoimmune disorders. There is also http://www.traders.co.uk/insulintrust/database/id73.htm
Extractions: The hair loss may result in round bald patches on the scalp (alopecia areata) or involve the loss of all facial and scalp hair (alopecia totalis). The loss of all body hair is called alopecia universalis. Alopecia postpartum is characterized by loss of significant hair following pregnancy and is usually temporary. When a patient is diagnosed with alopecia, the first question is usually about whether or not the hair will regrow. The answer is usually vague as each case is different. Regrowth of hair may occur in some patients; and in others, the hair loss is permanent. Back to top Idiopathic Thrombocytopenia Purpura (ITP) Chronic ITP is an autoimmune disease of primarily young to middle-age adults that is at least twice as common in females as in males. It is relatively insidious in its onset and is not associated with preceding viral infection. ITP resolves spontaneously only on rare occasions. ITP is a common disorder; in fact, it may be the most common of all the autoimmune diseases in which the cell targeted by the immune system for auto-reaction has been clearly identified.
Vaccines: Auto-immunity, Vaccinations And Autism The linkage of vaccines to neurological disorders comes through the promotion ofan autoimmune process, triggered by the virus present in the vaccine together http://www.healing-arts.org/children/vaccines/vaccines-auto-immunity.htm
Extractions: For ease of navigation and reference in this very comprehensive and extensive section on vaccines we are posting the "Quick Index" for the entire contents at the beginning of each page. To jump immediately to the information available on Auto-immunity, Vaccines and Autism , please click here Overview
Vaccines: Other Vaccination Concerns damage, leading to learning disabilities and other nervous system disorders, or death Theargument for adjuvants evoking an autoimmune response does not hinge http://www.healing-arts.org/children/vaccines/vaccines-other.htm
The Immunesystem situation, immunological disorders can lead to overreactivity, for instance to proteinsin our own body (auto-immunity). Lupus is an auto-immune disease, and http://www.bacteriamuseum.org/niches/hwfbacteria/immunesystem.shtml
Extractions: Choose Exhibit Antibiotics Vaccination Our defenses against bacterial infection are active on several levels. Level 1: Prevention and removal. Our first defense is to prevent the survival and entry of pathogenic bacteria Level 2: Non-specific killing of bacteria. As if level 1 defense is not enough (and sometimes it isn't), our body has developed a non-specific, ever active, lethal weapon for those bacteria (and viruses as well), that succeed in entering sites where they can cause harm. This weapon is comprised of a number of compounds in our blood and bodily fluid called complement , that kill most bacteria when it comes into action. Moreover, certain white blood cells inspect our body constantly to scavenge for unwelcome guests, which are eaten alive when discovered. These defenses comprise our so-called
AMFI - Autoimmune Diseases is often of great importance to patients who live with autoimmune disorders. J. Leclere G. Weryha Stress and autoimmune Endocrine Diseases Hormone Research http://www.amfoundation.org/autoimmune.htm
Extractions: INTRODUCTION The resources contained in this guide relate to alternative and complementary therapy options available for autoimmune diseases. There are many more books and resources available. The following have been selected as key resources that will lead you to many more. They have been carefully categorized and factually described to facilitate your own research. Some key conventional medicine research resources have been included to provide basic information on the process of diagnosis and orthodox treatments before exploring other options. Conventional Approaches Alternative Approaches [Back to Contents]
Endocrine Disorders Index Page And Site Map Endocrine disorders Home Page The Endocrine disorders Home Page links Hashimoto'sThyroiditis symptoms, diagnosis and treatment of autoimmune thyroiditis; http://www.endocrineweb.com/indexpg.html
Extractions: UPDATED, NOVEMBER, 2002 Endocrine Disorders Home Page What is Endocrinology and Endocrine Surgery? Introduces Endocrinology and Endocrine Surgery. Gives a one-sentence description of each gland and the purpose of the hormones each one secretes. A good place to start! What are Hormones? Just protein messengers which help cells talk to each other. Definitions of Endocrinology Terms. parathyroid, parathyroid surgery
Auto-Immune Protocol illnesses. Some common autoimmune disease disorders include rheumatoidarthritis (not osteoarthritis) and lupus erythematosus. http://www.drlam.com/opinion/auto-immune_protocol.cfm
Extractions: Auto-immune disease represents a class of disease where the body's immune system has become dysfunctional. The body's immune system attacks itself, causing many illnesses. Some common auto-immune disease disorders include rheumatoid arthritis (not osteoarthritis) and lupus erythematosus. Lupus erythematosus - Model of Auto-immune Disease Lupus erythematosus is a chronic inflammatory disorder of the connective tissue . 90 percent of those afflicted are women, and mostly occur in young adults. It is an autoimmune disease.
Extractions: Coming Soon! Medical Glossaries Supplements Diabetes Cancer Senior Resources ... Contact Us Allergies Allergies General Information - What are allergies and how are they treated? Drug Allergies - People sometimes become allergic to drugs that they have taken before with no problems. This can also be a complicating factor in treatment programs. Latex Allergies - Latex allergy develops after some sensitizing contact with latex. Rubber gloves are the main source of allergic reactions. Alzheimer's/Dementia Alzheimer's Disease - Alzheimers disease is the most common cause of progressive dementia in the elderly.
Meetings: Dermatology Section autoimmune and allergic disorders of the mouth. 11.30 am, auto-immuneblistering disorders of mucosa - how can the laboratory help? http://www.rsm.ac.uk/academ/smtderma.htm
