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Completely revised and updated, the Second Edition of the Atlas of Atherosclerosis Progression and Regression contains new material and new illustrations from Dr. Stary's groundbreaking work in the field of atherosclerosis diagnosis, prevention, and treatment. Over 100 photographs show arterial and lesion structure and individual components in unprecedented detail. These images allow you to compare and contrast healthy arteries with those developing and regressing lesions. They illustrate the successive steps in the natural history of human atherosclerotic disease from the microscopically visible, lipid-filled macrophages in susceptible locations of arteries to lesion forms that produce clinical symptoms. The book provides an up-to-date, pathology-based framework of morphologies of atherosclerotic vascular lesions that serves as a basis for correlation with morphologies determined by a variety of clinical imaging techniques. Demonstrating the evolution of arterial lesions form the clinically silent the clinically relevant, An Atlas of Atherosclerosis Progression and Regression is a teaching aid and diagnostic tool for recognizing changes in lesion progression, stabilization, or regression.About the author: Dr. Stary is Professor of Pathology at the Louisiana State University Health Sciences Center in New Orleans. He came to New Orleans via the Departments of Pathology of the McGill (Montreal) and Yale (New Haven) Medical Schools. For 7 years, Dr. Stary also served as chairman of the American Heart Association's Committee on Vascular Lesions. ... Read more

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Covering the most devastating disease in the Western world, this handbook and ready reference provides a comprehensive account of the different stages and factors in the development of the atherosclerotic plaque.
Each chapter is written by experts in the field and highlights the role of specific mediators of atherosclerotic plaque development, as well as potential therapeutic targets. A large amount of this up-to-date information is conveyed by way of tables and schematic figures, in a readily comprehensible manner.
A must-have for master and PhD students, researchers, MDs and lecturers in vascular biology and cardiology, as well as for academics and scientists in the pharmaceutical industry.
... Read more

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The World's Leading Experts Provide all the 'Essentials' Needed to Manage Patients in the Office, on the Ward, and in the Intensive Care Unit!Written by key opinion leaders in the field of cardiology, Dyslipidemia Essentials integrates the latest clinical guidelines and trials into a practical step-by-step guide to the management of dyslipidemia. Important clinical trials, common management pitfalls, and other cardiovascular risk reduction measures are also emphasized.Topics include:Step-by-step guide to intensive LDL lowering;NCEP ATP III and AHA/ACC guideline Updates;Treatment of low HDL cholesterol and elevated triglyceride; 73 dyslipidemia trials and 17 drug summaries ... Read more

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Atherosclerosis is the most common cardiovascular disorder in western societies and is rapidly becoming similarly prevalent in the underdeveloped world. Written by notable authorities and providing text rich in illustrative figures, Molecular Mechanisms in Atherosclerosis addresses the fundamental mechanisms underlying atherothrombosis and delineates current views of the molecular and cellular basis of the process. The editor approaches the issue from a mechanistic perspective, and does so in the context of contemporary knowledge of molecular and cellular pathobiology.

The book provides an epidemiological overview of atherosclerotic vascular disease, followed by a review of the genetics and genetic epidemiology. It focuses on the four fundamental mechanisms common to all risk factors for atherosclerosis: inflammation, oxidative stress, thrombosis, and endothelial dysfunction and the mechanisms under lying for common risk factors for atherogenesis: dyslipidaemias, diabetes mellitus, hypertension, and smoking. The book then discusses the recently proposed risk factors hyperhomocysteinemia and infection and rational molecular therapies to prevent and combat established atherothrombotic disease.

Taken together, these chapters offer a broad review of the molecular and cellular mechanisms of atherothrombogenesis. The topics covered and the order of presentation were carefully chosen to clarify the complexity of the disease process. Armed with the information contained in this text, you can confidently explore cutting-edge research with insight and foresight regarding their implications for prevention and treatment. ... Read more

Customer Reviews (1)

Blood flow [hemodynamics] causes atherosclerosis,
Atherosclerosis including coronary heart disease and myocardial infarction can and do occurat any and alllevels of blood cholesterol. Atheroclerosis is NOT a lipid disease.The rise of the cholesterol hypothesis is attributed to misplaced faithin statistical studies and faulty extrapolations from clinical trials.All the data from autopsy specimens, model hydraulicsystems, the laws of fluid mechanics ,mathematical analysis and the production of hemodynamicallyinducedarterial lesions in dogs compel the conclusion that atherosclerosis is the effect of the forces of the flowing blood {diminished lateral[wall]pressure at sites of predilection characterized by curvature,branching, bifurcation and serpentine flow. Let us put our research effort into this direction rather than perpetuating the diet-cholesterol heart disease myth. Meyer Texon, MD Associate Professor ofd Forensic Medicine New York University School of Medicine Website members.aol.com/mtexon email mtexon@aol.com ... Read more

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Diabetes is an autoimmune, inflammatory disease affecting many different organ systems and exhibiting both primary and secondary defects. Because diabetes affects a wide range of cellular systems, a multidisciplinary effort has been mounted over the past several decades using a wide range of investigative techniques and methodologies in order to identify molecular mechanisms responsible for cellular dysfunction. Because primary defects at various levels of sub-cellular signaling, intracellular calcium handling, protein expression and energy regulation are often a primary consequence of diabetes.

This volume is a compilation of new multidisciplinary research that will broaden our current understanding of diabetes and cardiovascular disease as well as provide the basis for the development of novel therapeutic interventions.

Product Description
New discoveries in genetics, molecular, and cell biology are not only enhancing our understanding of the etiology and progression of disease, but are finding applications in the development of new drugs or the implementation of new kinds of therapy. This book provides an in-depth review of emerging areas in biomedical research at the interface of science and clinical medicine. Written by a team of well-known experts, Lipidology: Translational Medical Science presents an authoritative overview of key advances in biomedical research and reviews the most important recent advances in lipidology, highlighting their relationship to cardiovascular disease. ... Read more

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Two cardiologists present their revolutionary new program for preventing and reversing atherosclerosis, integrating principles of exercise, stress reduction, dietary modification, and kicking the cigarette habit into a blueprint for health. ... Read more

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This book covers many aspects of atherogenesis, with particular emphasis on lipid and lipoprotein metabolism. It includes all aspects of the regulation of cholesterol homeostasis and the importance of each pathway. Also explored are the roles of nuclear hormone receptors on lipid and lipoprotein metabolism and their complex roles in atherogenesis. The book further discusses how genetic studies can help understand the complexities that mediate these aspects of atherogenesis.

Product Description
Atherosclerosis is a degenerative condition in which arteries build up deposits called plaques (atheromas) which consist of lipids (mainly cholesterol), connective tissue and smooth muscle cells originating from the arterial wall. Plaques develop quietly over a period of years and are unnoticeable until there is an interruption in the normal flow of blood. Plaques may partially or totally block the blood's flow through an artery. Two things that can happen where plaques occur are: bleeding (haemorrhage) into the plaque; and formation of a blood clot (thrombus) on the plaque's surface. Atherosclerosis affects large and medium-sized arteries. The type of artery and where the plaque develops varies with each person. Atherosclerosis research has witnessed startling progress in recent years, partially due to new drugs as well as to breakthroughs in molecular medicine. ... Read more

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In Atherosclerosis: Experimental Methods and Protocols, Angela Drew and a panel of experts have assembled a comprehensive collection of traditional and cutting-edge techniques for investigating this disease and its possible treatments. Each readily reproducible method includes step-by-step instructions and practical information regarding sample collection, the choice of animal model system, experimental design, and practical data analysis techniques. Comprehensive and richly detailed, Atherosclerosis: Experimental Methods and Protocols enables all biomedical investigators to select those optimized techniques that may be most fruitfully used to study the development, progression, and treatment of atherosclerotic lesions today. ... Read more

Customer Reviews (1)

A Must Have Resource For Vasular Research
This book is a necessary resource for anyone in the field of vascular pathology, medical device pathology, or vascular research in general.Whether you are a study sponsor, pathologist, study director, scientist, research associate/assistant or laboratory manager/tech, you should familiarize yourself with this book.It allows the reader to make a better-informed decision regarding the type of research model appropriate to the type of research being performed.It also describes invaluable techniques (e.g. proper excision of treated arteries/veins, tissue processing, embedding techniques, and special stains). The contributors are all experts in atherosclerotic research and there are many helpful references in the back of the book. For those who do not like blindly paying a hundred dollars for a book, here are the chapters:

1. Animal Models of Diet-Induced Atherosclerosis
2. Mechanical Injury Models
3. Genetically Manipulated Models of Atherosclerosis in Mice
4. Lipoprotein Isolation and Analysis from Serum by Preparative
Ultracentrifugation
5. Separation of Plasma Lipoproteins in Self-Generated Gradients of
Iodixanol
6. Fractionation of Lipoprotein Subclasses in Self-Generated Gradients of
Iodixanol
7. Detecting Cholesteryl Ester Transfer Protein in Plasma
8. Determination of Plasma Homocysteine
9. Assay for Serum Glycated Lipoproteins
10. Lipoprotein(a) Quantitation
11. Isolation and Characterization of Glycosaminoglycans from Human
Atheromatous Vessels
12. Culture of Human Smooth Muscle Cells
13. Culture of Human Endothelial Cells
14. Assay for Cell Migration and Invasion of Vascular Smooth Muscle Cells
15. Collection and Processing of Arterial Specimens for Histological
Analysis
16. Intravascular Ultrasound Imaging in the Quantitation of
Atherosclerotic Tissue
17. Identification of Cell Types and Quantification of Lesion Composition
18. Nonradioactive In Situ Hybridization of Atherosclerotic Tissue
19. Evaluation of Angiogenesis
20. Evaluation of Cell Proliferation in Human Atherosclerotic Lesions
21. Gene Transfer to the Vasculature
22. A Pig Model of Vein Graft Disease

I hope this helps you and/or your company; I know it has helped me.
... Read more

Product Description
Atherosclerosis is a degenerative condition in which arteries build up deposits called plaques (atheromas) which consist of lipids (mainly cholesterol), connective tissue and smooth muscle cells originating from the arterial wall. Plaques develop quietly over a period of years and are unnoticeable until there is an interruption in the normal flow of blood. Plaques may partially or totally block the blood's flow through an artery. Two things that can happen where plaques occur are: bleeding (hemorrhage) into the plaque; and formation of a blood clot (thrombus) on the plaque's surface. Atherosclerosis affects large and medium-sized arteries. The type of artery and where the plaque develops varies with each person. Atherosclerosis research has witnessed startling progress in recent years, partially due to new drugs as well as to new breakthroughs in molecular medicine. ... Read more

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Selected as an outstanding book in vascular surgery by members of the Society for Vascular Surgery.*This unique new text describes the current understanding of the etiology and pathogenesis of human atherosclerosis. It also details the methods for quantitating and characterizing both experimental and clinical lesions, and describes the methods for preparing available animal models.Providing an in-depth review of each of these topics, the text organizes the information in one volume for the convenience of the reader. The text is divided into two sections. First is a description of the cell biology, biochemistry and pharmacology of normal vessels and of atherosclerotic human lesions, with details of the methods to accurately characterize and quantitate the disease. Secondly, it presents a description of the methods for preparing the available experimental animal models, including a discussion of the distribution and pathological characteristics of the lesions.It also includes comparisons of human atherosclerosis and experimental animal models. Intended to provide a basis for expediting future research in this priority health care area, this text compiles the available information for those who treat patients with atherosclerosis or who are involved in atherosclerosis research. It is of particular interest to students, physicians, and academic and commercial researchers. ... Read more

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Despite recent advances in the diagnosis and treatment of symptomatic atherosclerosis, available traditional screening methods for early detection and treatment of asymptomatic coronary artery disease are grossly insufficient and fail to identify the majority of victims prior to the onset of a life-threatening event. In Asymptomatic Atherosclerosis: Pathophysiology, Detection and Treatment, Dr. Morteza Naghavi and leading authorities from the Society for Heart Attack Prevention and Eradication (SHAPE) present a new paradigm for the screening and primary prevention of asymptomatic atherosclerosis.

The text focuses on accurate, yet underutilized, measures of subclinical atherosclerosis, notably coronary artery calcium scanning and carotid intima-media thickness measurement. The authors introduce a comprehensive approach to identifying the vulnerable patients (asymptomatic individuals at risk of a near future adverse event). Additional chapters discuss future directions towards containing the epidemic of atherosclerotic cardiovascular disease using innovative solutions such as preemptive interventional therapies (bioabsorbable stents) for stabilization of vulnerable atherosclerotic plaques, mass unconditional Polypill therapy for population-based risk reduction, and ultimately vaccination strategies to prevent the development of atherosclerosis.

Up-to-date and authoritative, Asymptomatic Atherosclerosis: Pathophysiology, Detection, and Treatment is a must-have for any cardiologist or primary care physician who wishes to practice modern preventive cardiology and manage the increasing number of asymptomatic atherosclerotic patients.

• Outlines more accurate measures of risk (coronary artery calcium and carotid intima-media thickness) than traditional risk factors (total cholesterol, LDL cholesterol, HDL cholesterol)

• Presents new multipronged strategies to aid in the early detection and treatment of high risk asymptomatic patients

Customer Reviews (2)

This book should be on the bookshelf for any physician who has an interest in atherosclerosis.
"Asymptomatic Atherosclerosis", edited by Morteza Naghavi, is a comprehensive book assembled with the standpoint, that vascular death, heart attack and stroke should be prevented primarily with a new approach: rather than judging risk from traditional risk factors of atherosclerosis, prevention should be directed by the severity of atherosclerosis itself.

Recent research has documented that assessment of risk, based on risk factors of atherosclerosis, predicts very poorly who will suffer vascular death, myocardial infarction and stroke in the near future. In fact, using this approach for identifying the high risk person and offering intensive treatment has never been proven to reduce morbidity or mortality. Therefore, this book with a refreshing approach, where early (or advanced) signs of the disease (asymptomatic atherosclerosis), independent of risk factors of the disease, should be taken as a serious marker of risk, is very welcome.

The book therefore includes chapters dealing with pathogenesis, risk factors and new biomarkers of atherosclerotic cardiovascular disease. Especially, the potential of noninvasive imaging to disclose who are at the highest risk is covered in detail. Also, chapters dealing with how to use the biomarker and imaging information, including new treatment paradigms such as the "polypill". In general, the authors of chapters are well-accredited scientists with decades of experience within their fields.

This book should be on the bookshelf for any physician who has an interest in atherosclerosis. It summarizes recent science with established knowledge and the only thing missing that comes to this reviewers mind, is that an "easy read" version for general practitioners would be needed when treatment of asymptomatic atherosclerosis evolves for the general population.

Copenhagen, August 14th 2010

Henrik Sillesen, MD, DMSc
Chairman, Dept. of Vascular Surgery
Rigshospitalet, Univ. of Copenhagen
Denmark

Asymptomatic Atherosclerosis will be a welcome addition to the busy cardiovascular clinician's library.
Asymptomatic Atherosclerosis, edited by Morteza Naghavi et al, provides the clinician with comprehensive state-of-the-art information regarding early detection and treatment of atherosclerotic cardiovascular disease.

The book starts with chapters which provide current knowledge regarding the pathophysiology of atherosclerosis, emphasizing points of vulnerability at various points in the cascade leading from micro to macro disease manifestations.There are very high quality color pathology pictures which help illustrate the important points.This is followed by several chapters dealing with methods of assessing risk, including biological markers, imaging of atherosclerosis, and functional assessment of the atherosclerotic process.The final chapters are concerned with current methods for treating asymptomatic atherosclerosis, including pharmacological, non-pharmacological, and invasive approaches for plaque stabilization.

This book includes in one source both the current knowledge and the potential future approaches to one of the most important challenges facing both the Internist and Cardiovascular specialist.The best way to impact on the future wave of disease is prevention, and this book provides a tool for understanding both where we are and where we are going.It will be useful for the practicing clinician who needs review of the current state of the art regarding prevention, and who want insight into future directions for both therapy and investigation.The book is well-written and profusely illustrated with both clinical images and illustrations.

I think that Asymptomatic Atherosclerosis will be a welcome addition to the busy cardiovascular clinician's library.
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Product Description
Prevention of Cardiovascular Disease is a state-of-the-art/science review providing a number of key Web resources/websites for additional information. It may be used to obtain current and useful information on prevention of cardiovascular disease, and to quickly and easily search the Web. With this book one may take charge, control and responsibility for prevention of cardiovascular disease and make informed decisions with their healthcare provider/physician, and live a healthier, happier, longer and more productive/enjoyable life.

Product Description
Non-Invasive Imaging of Atherosclerosis is a primer,reference and review of some of the key features of current activitiesin the field of atherosclerosis. The Editors' goal is to providematerial and stimulating ideas to basic scientists and clinicalresearchers in order to extend the application of vascular imaging andto further develop methods suitable for investigation of the arterialwall. The first section presents current knowledge about pathology, vascularmechanics and compensatory mechanisms active during atherogenesis. Itexplores the early lesion, complications of plaques and earlydetection of plaques. Section II reviews several key methodological issues of B-modeultrasound imaging and some of the most current data. QuantitativeB-mode ultrasound is an established non-invasive tool widely used inlarge epidemiologic studies and interventional clinical trials ofatherosclerosis. The last section addresses the most promising areas of development invascular imaging. This involves new techniques to evaluate theatherosclerotic bed, to follow atheroma progression/regression and toevaluate vascular mechanics in atherosclerotic arteries. The lastchapter places the application of non-invasive imaging in perspective. ... Read more

Customer Reviews (1)

Review from International Juornal of Cardiac Imaging
"... this is a very interesting book that provides a very complete overview of the current state and future applications of non-invasive imaging of atherosclerosis." ... Read more

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National Institutes of Health, Bethesda, MD. Discusses the discovery, biological roles, and regulation of endothelial nitric oxide (NO), basic mechanisms that lead to dysfunction, clinical studies, and therapeutic strategies developed to ameliorate endothelial dysfunction. For students, residents, clinicians, and researchers. DNLM: Endothelium, Vascular-physiology. ... Read more

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Heart attack or bypass surgery? - or even if not- if you are overweight, have high blood pressure, high blood sugar, diabetes, high cholesterol, heart disease, or a family history of any, read this and then keep it for reference. ... Read more

Customer Reviews (5)

I bought it by mistake, as I thought itwas from John A.Mac Dougall the author of the Mc Dougall Plan
I bought it by mistake, as I thought itwas from John A.Mac Dougall the author of the Mc Dougall Plan, he well known Doctor thar runs the 12 Days to Dynamic Health.

E for effort
I am agreeing to the comment of "E for effort" on this book.

This book describes the author's attemps to improve his condition and how he suceeded. But he admits in his book that he is not sure which ones actually worked. Plus, the author also takes diabetes medications, along with other medicines and supplements. My main concern is what worked for him probably won't work for someone reading this book.

This book does not really provide a clear picture on what to do. He made so many changes on the medications and supplements, it is hard to say what worked.

One can find the general imformation presented in this book on "Diet", "Exercise" and "Stress management" (relating to clog arteries & heart diseases) through the internet. I didn't gain any new information by reading this book.

The printing of this book is also done in a very strange way.
The text is printed at the center, occupying only the center area with a lot of spaces around, so about half of the page is blank.

Pleasing, but could have been better
The author's intentions were quite noble. Still, the writing was rather stiff. I give it an E for effort, but...would I buy a sequel? No way.

From calorie charts to insurance claims
Unclog Your Arteries: How I Beat Atherosclerosis is the personal testimony of Gene McDougall, a man who used diet changes, vitamin supplements, prescription medications, basic lifestyle changes, and more to recover after his own clogged arteries nearly killed him in a heart attack. From calorie charts to insurance claims, Unclog Your Arteries is filled with useful forms and advice, and a welcome, highly recommended supplement (though emphatically not a replacement for a doctor's diagnosis and advice) for anyone who needs to improve their heart health and quickly.

Bypass Prevention Made Easy
This is an excellent guidebook for those who want to avoid heart bypass surgery. Case in point - page 28 lists the cholesterol component target numbers needed to reverse artery clogging. That page alone is worth the price of the book many times over. I also appreciated how easy the book was to read, understand and put into practice. I was afraid it would be filled with all kinds of incomprehensible medical terms, but it was written in plain, everyday English. There were even blank forms to photocopy and use in keeping my medical records organized. For people who are lazy or easily overwhelmed by a complicated or unpleasant regimen, this book is a dream come true. The author even explains how it's possible to control weight without counting calories.

By skipping over the charts and tables, it took less than 45 minutes to read this book the first time. I say the first time, because I have read it several times. It has turned out to be a great reference source - it even has extra-wide margins for writing notes.

From now on, when the occasion calls for it, I'm giving this book to my friends as a "get well" gift, instead of cards or flowers. ... Read more